[细胞色素P450 19A1、谷胱甘肽S-转移酶M1、谷胱甘肽S-转移酶T1和谷胱甘肽S-转移酶P1基因多态性与子宫内膜异位症的相关性]
[Correlation between polymorphism of CYP19A1, GSTM1, GSTT1 and GSTP1 gene and endometriosis].
作者信息
Tuo Y, Yang J, Chen X J, Liu F
机构信息
Reproductive Medicine Center, the Affiliated Hospital of Inner Mongolia Medical University, Huhehot 010050, China.
Renmin Hospital of Wuhan University, Reproductive Medicine Center, Wuhan, Wuhan 430060, China.
出版信息
Zhonghua Yi Xue Za Zhi. 2019 Feb 19;99(7):515-519. doi: 10.3760/cma.j.issn.0376-2491.2019.07.008.
To study the association between polymorphisms in CYP19A1 rs2899470, GSTM1, GSTT1, and GSTP1 rs1695 and the development of endometriosis. Between October 2015 and October 2017, 262 endometriosis patients and 275 control subjects were recruited from the Affiliated Hospital of Inner Mongolia Medical University. Genotyping was conducted using polymerase chain reaction-coupled with restriction fragment length polymorphism and multiplex allele specific polymerase chain reaction. Individuals carrying the TT genotype of CYP19A1 rs2899470 expressed a higher risk of endometriosis than that carrying the GG genotype (0.01), and the adjusted was 2.33 (95% 1.27-4.33). In addition, individuals with the CYP19A1 rs2899470 the TT genotype aggravated the condition of endometriosis (2.27, 95% 1.05-4.90). However, GSTM1, GSTT1 and GSTP1 rs1695 polymorphisms did not affect the pathogenesis of endometriosis. Our results suggested that CYP19A1 rs2899470 polymorphism is associated with the risk of endometriosis and the risk of disease.
研究细胞色素P450 19A1（CYP19A1）基因rs2899470、谷胱甘肽S转移酶M1（GSTM1）、谷胱甘肽S转移酶T1（GSTT1）和谷胱甘肽S转移酶P1（GSTP1）基因rs1695多态性与子宫内膜异位症发生发展之间的关联。2015年10月至2017年10月期间，从内蒙古医科大学附属医院招募了262例子宫内膜异位症患者和275例对照者。采用聚合酶链反应结合限制性片段长度多态性和多重等位基因特异性聚合酶链反应进行基因分型。携带CYP19A1 rs2899470基因TT基因型的个体患子宫内膜异位症的风险高于携带GG基因型的个体（P = 0.01），校正后比值比为2.33（95%可信区间为1.27 - 4.33）。此外，CYP19A1 rs2899470基因TT基因型的个体使子宫内膜异位症病情加重（比值比为2.27，95%可信区间为1.05 - 4.90）。然而，GSTM1、GSTT1和GSTP1 rs1695多态性并未影响子宫内膜异位症的发病机制。我们的研究结果表明，CYP19A1 rs2899470多态性与子宫内膜异位症的发病风险及病情相关。
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