Laboratory of Cancer Genetics, Department of Pathology, Polish Mother's Memorial Hospital Research Institute, Rzgowska 281/289, 93-338 Lodz, Poland.
Department of Operative Gynaecology and Oncological Gynaecology, Polish Mother's Memorial Hospital Research Institute, Rzgowska 281/289, 93-338 Lodz, Poland.
Int J Mol Sci. 2020 Nov 3;21(21):8235. doi: 10.3390/ijms21218235.
Endometriosis is defined as the presence of endometrial foci, localized beyond their primary site, i.e., the uterine cavity. The etiology of this disease is rather complex. Its development is supported by hormonal, immunological, and environmental factors. During recent years, particular attention has been focused on the genetic mechanisms that may be of particular significance for the increased incidence rates of endometriosis. According to most recent studies, ESR2 and CYP19A1 genes may account for the potential risk factors of infertility associated with endometriosis. The paper presents a thorough review of the latest reports and data concerning the genetic background of the risk for endometriosis development.
子宫内膜异位症是指子宫内膜病灶出现在子宫腔以外的部位。其病因较为复杂，发病机制与激素、免疫和环境等因素有关。近年来，人们对遗传机制的关注日益增加，因为这些机制可能与子宫内膜异位症发病率的增加密切相关。根据最近的研究，ESR2 和 CYP19A1 基因可能是导致子宫内膜异位症相关不孕的潜在危险因素。本文对子宫内膜异位症发病风险的遗传背景的最新研究进展进行了综述。
