Polymorphism, along with Deletion of and Genes, Strongly Influences Female Infertility Risk.

Oxidative stress has a fundamental role in the pathophysiology of various conditions, like infertility. This case-control study was performed to assess the potential role of , , and in modifying individual predisposition to female infertility. Genotyping of 201 women with established infertility and 161 fertile female controls was performed, and statistical associations were analyzed. For carriers of null genotype along with allele, there is a significant association with female infertility risk (OR 7.023; 95% CI (3.627-13.601; < 0.001), and, also for carriers of null genotype along with the genotype (OR 24.150; 95% CI (11.148-52.317; < 0.001). A positive association with female infertility risk for carriers of the allele in and null genotypes in (OR 11.979; 95% CI (4.570-31.400; < 0.001) or (OR 13.169; 95% CI (4.518-38.380; < 0.001) was found. When both are deleted, the risk of developing female infertility is significant, independently of the genotype; when all the presumed high-risk genotypes are present, we found a significant association with female infertility risk (OR 47,914; 95% CI (14,051-163,393; < 0.001).