Zhang P F, Wang Y P, Yuan X X, Tao Q, Liu Y F, Pang L J, Li X, Li H H, Song X Q
Department of Psychiatry, First Affiliated Hospital, Zhengzhou University, Zhengzhou 450052, China.
Zhonghua Yi Xue Za Zhi. 2019 Feb 19;99(7):520-524. doi: 10.3760/cma.j.issn.0376-2491.2019.07.009.
To explore the possible role of Irisin in antipsychotic drug-induced insulin resistance and abdominal obesity in patients with schizophrenia and to provide a theoretical basis for the prevention of antipsychotic drug-induced obesity. Fifty-five patients with first-episode schizophrenia, from the First Affiliated Hospital of Zhengzhou University, between January 2016 and December 2017, were admitted as well as fifty healthy controls during the same period. Serum Irisin levels were measured by enzyme-linked immunosorbent assay (ELISA). Fasting blood glucose (FBG), fasting insulin (INS), homeostasis model assessment of insulin resistance (HOMA-IR) and triglyceride (TG), total cholesterol (TCHO), highdensity lipoprotein (HDL), low density lipoprotein (LDL) were detected. The average Irisin level ((233±228) mmol/L) was higher than that in the normal control group ((124±89) mmol/L) (<0.05).Repeated measurement analysis of variance showed that the average levels of the height, waist, FBG, INS, TCHO, TG, HDL, LDL, BMI, HOMA-IR and Irisin at the end of the 12(th) and 24(th) week's treatment were higher than baseline (<0.05). After correlation analysis, the level of Irisinat baseline was positively correlated with HOMA-IR (=0.383, <0.05). At the 12(th) week, the level of Irisin was positively correlated with waist circumference, and HOMA-IR (=0.360, =0.475, all <0.05). Multiple linear regression analysis showed that at the 12(th) week's treatment, compared with the baseline period, changes of Irisin was positively correlated with waist circumference and HOMA-IR, respectively (=0.453, =0.420, both <0.05). Irisin may be involved in the process of metabolic regulation and bean early predictor of antipsychotic drug-induced insulin resistance and abdominal obesity.
探讨鸢尾素在精神分裂症患者抗精神病药物所致胰岛素抵抗和腹部肥胖中的可能作用，为预防抗精神病药物所致肥胖提供理论依据。选取郑州大学第一附属医院2016年1月至2017年12月收治的55例首发精神分裂症患者以及同期50例健康对照者。采用酶联免疫吸附测定法（ELISA）检测血清鸢尾素水平。检测空腹血糖（FBG）、空腹胰岛素（INS）、胰岛素抵抗稳态模型评估（HOMA-IR）以及甘油三酯（TG）、总胆固醇（TCHO）、高密度脂蛋白（HDL）、低密度脂蛋白（LDL）。精神分裂症患者鸢尾素平均水平为（233±228）mmol/L，高于正常对照组的（124±89）mmol/L（P<0.05）。重复测量方差分析显示，治疗12周和24周时身高、腰围、FBG、INS、TCHO、TG、HDL、LDL、BMI、HOMA-IR及鸢尾素的平均水平均高于基线水平（P<0.05）。相关性分析显示，基线时鸢尾素水平与HOMA-IR呈正相关（r=0.383，P<0.05）。治疗12周时，鸢尾素水平与腰围、HOMA-IR呈正相关（r=0.360，r=0.475，均P<0.05）。多元线性回归分析显示，治疗12周时，与基线期相比，鸢尾素变化量分别与腰围、HOMA-IR呈正相关（r=0.453，r=0.420，均P<0.05）。鸢尾素可能参与代谢调节过程，是抗精神病药物所致胰岛素抵抗和腹部肥胖的早期预测指标。
