脊椎动物视杆光感受器中光转导级联反应的建模与模拟
Modeling and simulation of phototransduction cascade in vertebrate rod photoreceptors.
作者信息
Pan Guofeng, Tan Jinglu, Guo Ya
机构信息
Ministry of Education, Key Laboratory of Advanced Process Control for Light Industry, Jiangnan University, Wuxi, 214122, China.
University of Missouri, Columbia, MO, 65211, USA.
出版信息
BMC Ophthalmol. 2019 Feb 20;19(1):55. doi: 10.1186/s12886-019-1048-7.
BACKGROUND
The activation of phototransduction cascade in rod photoreceptors has been well studied in literature, but there is a lack of a mature kinetic model structure covering both the activation and inactivation processes.
METHODS
In this work, a kinetic model structure is developed to describe the major activation and inactivation processes in vertebrate rod photoreceptors with the electroretinogram (ERG) as output. Simulation was performed to validate developed model structure.
RESULTS
The developed model structure could fit experimental data with small error.
CONCLUSIONS
The result indicated that the developed model structure could show the inactivation process of phototransduction cascades in the rod photoreceptors.
背景
视杆光感受器中光转导级联反应的激活在文献中已有充分研究，但缺乏一个涵盖激活和失活过程的成熟动力学模型结构。
方法
在本研究中，开发了一种动力学模型结构，以视网膜电图（ERG）作为输出，描述脊椎动物视杆光感受器中的主要激活和失活过程。进行模拟以验证所开发的模型结构。
结果
所开发的模型结构能够以较小误差拟合实验数据。
结论
结果表明，所开发的模型结构能够显示视杆光感受器中光转导级联反应的失活过程。
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