Abdel-Khalik Mohamed Y, Mahrous Shereen A, Shanab Alsayed A, Alshehri Abdullah M, Rashed Mustafa H, Azoz Ayman M
Department of Cardiac Technology, College of Applied Medical Sciences, Dammam, Saudi Arabia.
Department of Family Medicine, Primary Health Care Center in Dammam, Ministry of Health, Saudi Arabia.
Saudi J Med Med Sci. 2017 May-Aug;5(2):124-129. doi: 10.4103/1658-631X.204854. Epub 2017 Apr 20.
To determine the usefulness of monitoring morning blood pressure surge (MBPS) to predict cardiovascular events in patients with essential hypertension.
A total of 81 patients (43 males and 38 females) with a mean age of 55.9 ± 9.8 years with essential hypertension were included in the study. Twenty-four hour ambulatory blood pressure (BP) monitoring was carried out to record MBPS. All patients were followed up for 36 months for cardiovascular events.
Mean MBPS was 26.23 ± 10.17 mmHg. Nineteen patients (23%) who experienced a cardiovascular event during the follow-up period had higher MBPS than patients who did not experience a cardiovascular event ( < 0.0001). MBPS was positively correlated with interventricular septum thickness ( = +0.38 and = 0.000), left atrial size ( = +0.39 and = 0.000), 24-h mean systolic BP ( = +0.36 and = 0.001) and total cholesterol level ( = +0.23 and = 0.003). MBPS was negatively correlated with high-density lipoprotein-cholesterol ( = -0.37 and = 0.001).
MBPS can be used as a biomarker for a cardiovascular disease event in hypertensive patients.
确定监测清晨血压骤升（MBPS）对预测原发性高血压患者心血管事件的作用。
本研究纳入了81例原发性高血压患者（43例男性和38例女性），平均年龄55.9±9.8岁。进行24小时动态血压监测以记录MBPS。所有患者随访36个月以观察心血管事件。
平均MBPS为26.23±10.17 mmHg。随访期间发生心血管事件的19例患者（23%）的MBPS高于未发生心血管事件的患者（P<0.0001）。MBPS与室间隔厚度呈正相关（r=+0.38，P=0.000）、左心房大小呈正相关（r=+0.39，P=0.000）、24小时平均收缩压呈正相关（r=+0.36，P=0.001）以及总胆固醇水平呈正相关（r=+0.23，P=0.003）。MBPS与高密度脂蛋白胆固醇呈负相关（r=-0.37，P=0.001）。
MBPS可作为高血压患者心血管疾病事件的生物标志物。
