Turak Osman, Afsar Baris, Ozcan Firat, Canpolat Ugur, Grbovic Enis, Mendi Mehmet Ali, Oksuz Fatih, Siriopol Dimitrie, Covic Adrian, Caliskan Mustafa, McFann Kim, Johnson Richard J, Kanbay Mehmet
Department of Cardiology, Türkiye Yüksek Ihtisas Education and Research Hospital, Ankara, Turkey.
J Clin Hypertens (Greenwich). 2014 Jul;16(7):530-5. doi: 10.1111/jch.12359. Epub 2014 Jun 12.
Early morning blood pressure surge (MBPS) is a risk factor for cardiovascular events (CVEs), but the relationship with uric acid is not well understood. The authors aimed to determine the association between MBPS and increased uric acid and the effect of elevated MBPS and uric acid combination on CVEs. A total of 921 patients underwent 24-hour ambulatory blood pressure monitoring and were followed for a median of 40 months. During this period, 103 (11.2%) CVEs occurred. There was a significant relationship between increasing quartiles of serum uric acid level and increasing values of MBPS (P<.0001). Patients in the highest quartile stratified by elevated MBPS and serum uric acid level had a 3.55 odds of major CVE compared with patients in the lowest quartile. Serum uric acid is associated with MBPS and development of new CVEs.
清晨血压激增（MBPS）是心血管事件（CVE）的一个危险因素，但与尿酸的关系尚不清楚。作者旨在确定MBPS与尿酸升高之间的关联，以及MBPS和尿酸升高联合作用对CVE的影响。共有921例患者接受了24小时动态血压监测，并进行了中位数为40个月的随访。在此期间，发生了103例（11.2%）CVE。血清尿酸水平四分位数增加与MBPS值增加之间存在显著关系（P<0.0001）。与最低四分位数的患者相比，按MBPS和血清尿酸水平升高分层的最高四分位数患者发生主要CVE的几率为3.55。血清尿酸与MBPS及新发CVE的发生有关。
