丹参酮IIA磺酸钠对小鼠心肌梗死后心功能的保护作用
Protective effects of sodium tanshinone IIA sulfonate on cardiac function after myocardial infarction in mice.
作者信息
Wu Peng, Du Yingqiang, Xu Zhihui, Zhang Sheng, Liu Jin, Aa Nan, Yang Zhijian
机构信息
Department of Cardiology, The First Affiliated Hospital of Nanjing Medical University Nanjing, P. R. China.
出版信息
Am J Transl Res. 2019 Jan 15;11(1):351-360. eCollection 2019.
Abstract
Sodium tanshinone IIA sulfonate (STS), a water-soluble derivative of tanshinone IIA, has been used in traditional Chinese medicine for many years. Many experiments have demonstrated that STS has anti-inflammatory, anti-apoptosis and angiogenesis effects. However, it is unclear whether STS has the same beneficial effects on myocardial infarction . The aim of our experiments was to investigate whether STS could improve cardiac function and prevent myocardial remodeling after myocardial infarction (MI) in mice. The MI model was established by surgical ligation of the left anterior descending (LAD) coronary artery. Then the mice were randomly divided into STS and untreated groups. The results of treatment for 3 weeks showed that STS could increase the survival rate, reduce the release of some inflammatory cytokines, inhibit cell apoptosis and promote angiogenesis. The study presents a new potential treatment method for ischemic heart disease.
摘要
丹参酮IIA磺酸钠（STS）是丹参酮IIA的水溶性衍生物，已在中药中使用多年。许多实验表明，STS具有抗炎、抗凋亡和血管生成作用。然而，尚不清楚STS对心肌梗死是否具有同样的有益作用。我们实验的目的是研究STS是否能改善小鼠心肌梗死后的心脏功能并预防心肌重塑。通过手术结扎左冠状动脉前降支（LAD）建立心肌梗死模型。然后将小鼠随机分为STS组和未治疗组。3周的治疗结果表明，STS可提高存活率，减少一些炎性细胞因子的释放，抑制细胞凋亡并促进血管生成。该研究提出了一种治疗缺血性心脏病的新的潜在方法。
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