Virk Gurjiwan Sing, Jafri Mikram, Mehdi Syed, Ashley Christopher
Department of Medicine, Albany Medical Center, Albany, NY, USA.
Department of Geriatrics, VA Stratton Medical Center, Albany, NY, USA.
J Gastrointest Oncol. 2019 Feb;10(1):12-18. doi: 10.21037/jgo.2018.09.01.
The US Preventive Services Task Force of Colorectal Cancer (USPSTF) recommends against continuing screening for colorectal cancer (CRC) past 75 years in adequately screened individuals. Survival and staging data for CRC that compares elderly . younger populations has not been published. This study aims to compare staging (0-4) of CRC in groups of 60-69, 70-79 and 80-89-year-old; also, to compare surgical and no treatment (i.e., no surgery) survival outcomes (5-10 years) in these age groups.
Male veterans within groups 60-69, 70-79 and 80-89 years of age who were diagnosed with CRC between 2000 and 2015 were selected from Veterans affairs national cancer cube registry.
Their staging, surgery or no treatment, and 5-10 years survival data was obtained from the cancer cube. Surgical and survival data was obtained only for stage 0-2 as surgery is currently the standard of treatment for these stages.
Highest number of CRC cases diagnosed across each age group was stage 1 with stage 2 being second. In surgical treatment group the survival was statistical different for 80-89 age group as compared to 60-69 (34.4%) and 70-79 (30.86%) although octogenarians did have a surprisingly high mean of 25.45%. The 5-10-year survival data for no treatment group (i.e., no surgery) was very poor.
美国结直肠癌预防服务工作组（USPSTF）建议，对于筛查充分的个体，75岁以后不应继续进行结直肠癌（CRC）筛查。比较老年人群与年轻人群的CRC生存和分期数据尚未发表。本研究旨在比较60 - 69岁、70 - 79岁和80 - 89岁组CRC的分期（0 - 4期）；此外，比较这些年龄组手术和未治疗（即不手术）的生存结局（5 - 10年）。
从退伍军人事务部国家癌症数据库中选取2000年至2015年间被诊断为CRC的60 - 69岁、70 - 79岁和80 - 89岁男性退伍军人。
从癌症数据库中获取他们的分期、手术或未治疗情况以及5 - 10年生存数据。由于手术是目前这些阶段的标准治疗方法，仅获取了0 - 2期的手术和生存数据。
各年龄组诊断出的CRC病例数最多的是1期，其次是2期。在手术治疗组中，80 - 89岁年龄组的生存率与60 - 69岁（34.4%）和70 - 79岁（30.86%）相比有统计学差异，尽管八旬老人的平均生存率高达25.45%，令人惊讶。未治疗组（即不手术）的5 - 10年生存数据非常差。
