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Use of PET and Other Functional Imaging to Guide Target Delineation in Radiation Oncology.使用 PET 和其他功能成像来指导放射肿瘤学中的靶区勾画。
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Long-term Results of Stereotactic Body Radiation Therapy in Medically Inoperable Stage I Non-Small Cell Lung Cancer.无法手术的 I 期非小细胞肺癌立体定向体部放疗的长期结果。
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Photons, protons or carbon ions for stage I non-small cell lung cancer - Results of the multicentric ROCOCO in silico study.光子、质子还是碳离子治疗 I 期非小细胞肺癌 - 多中心 ROCOCO 模拟研究结果。
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Optimal imaging surveillance after stereotactic ablative radiation therapy for early-stage non-small cell lung cancer: Findings of an International Delphi Consensus Study.立体定向消融放疗后早期非小细胞肺癌的最佳影像学监测：一项国际德尔菲共识研究的结果。
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Improved Survival of Stage I Non-Small Cell Lung Cancer: A VA Central Cancer Registry Analysis.Ⅰ期非小细胞肺癌生存率的提高：VA 中央癌症登记分析。
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Outcomes of invasive mediastinal nodal staging versus positron emission tomography staging alone for early-stage non-small cell lung cancer treated with stereotactic body radiation therapy.立体定向体部放疗治疗早期非小细胞肺癌时，侵袭性纵隔淋巴结分期与正电子发射断层扫描（PET）分期单独应用的结果比较。
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7-year follow-up after stereotactic ablative radiotherapy for patients with stage I non-small cell lung cancer: Results of a phase 2 clinical trial.I期非小细胞肺癌患者立体定向消融放疗后的7年随访：一项2期临床试验的结果
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医学上无法手术的I期非小细胞肺癌：最佳实践与长期结局

Medically inoperable stage I non-small cell lung cancer: best practices and long-term outcomes.

作者信息

Choi J Isabelle

机构信息

Department of Radiation Oncology, University of Maryland, Baltimore, MD, USA.

出版信息

Transl Lung Cancer Res. 2019 Feb;8(1):32-47. doi: 10.21037/tlcr.2018.06.11.

DOI:10.21037/tlcr.2018.06.11
PMID:30788233
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6351401/
Abstract

Early-stage non-small cell lung cancer (ES-NSCLC) currently represents a minority of all NSCLC diagnoses but, with ongoing refinement and improvement of treatment approaches, is a group with increasing likelihood of long-term disease control and survival. A significant proportion of this population will not be optimal candidates for definitive surgical resection due to tumor characteristics, patient frailty, or comorbid status. The clinical evidence to support the use of stereotactic body radiation therapy (SBRT) in patients with medically inoperable stage I NSCLC is growing as long-term data are obtained. In this review, initial workup, SBRT delivery considerations, recent trial data, and post-treatment surveillance of this population are discussed.

摘要

早期非小细胞肺癌（ES-NSCLC）目前在所有NSCLC诊断病例中占少数，但随着治疗方法的不断完善和改进，这一群体实现长期疾病控制和生存的可能性越来越大。由于肿瘤特征、患者身体虚弱或合并症状态，相当一部分这类患者并非确定性手术切除的最佳候选人。随着长期数据的获得，支持在医学上无法手术的I期NSCLC患者中使用立体定向体部放射治疗（SBRT）的临床证据正在增加。在本综述中，讨论了该人群的初始检查、SBRT实施注意事项、近期试验数据以及治疗后监测。