The eosinophil.

The eosinophil has characteristic granules containing a variety of mediators that may be important in the pathogenesis of cutaneous disease. Although numerous cutaneous diseases may be associated with tissue infiltration with eosinophils, in very few disorders, including Wells' syndrome, angiolymphoid hyperplasia with eosinophilia, and granuloma faciale, does the pattern of eosinophil infiltration contribute to the characteristic histopathologic picture. Immunofluorescence studies demonstrating eosinophil degranulation in the skin, particularly in urticaria and angioedema, have provided evidence to support a role for eosinophil mediators in the pathogenesis of certain cutaneous diseases.