Villarreal-Garza Cynthia, Lopez-Martinez Edna A, Muñoz-Lozano Jose Felipe, Unger-Saldaña Karla
Breast Cancer Center, TecSalud, Tecnologico de Monterrey, Monterrey 66278, Mexico.
Research and Breast Cancer Department, Mexican National Cancer Institute, Mexico City 14080, Mexico.
Ecancermedicalscience. 2019 Jan 22;13:894. doi: 10.3332/ecancer.2019.894. eCollection 2019.
The purpose of this review is to organise, summarise and critically assess existing knowledge on locally advanced breast cancer (LABC) among young women in Latin America. We discuss the most relevant findings in six sections: 1) epidemiology of breast cancer in young women in Latin America; 2) being young as a factor for worse prognosis; 3) LABC in young women in the region; 4) aggressive tumour behaviour among young women; 5) delays in diagnosis and treatment and 6) burden of advanced disease. We point out the need to dedicate resources to enhance earlier diagnosis and prompt referrals of young women with breast cancer; promote research regarding prevalence, biologic characteristics, outcomes and reasons for diagnosis and treatment delays for this age group; and finally, implement supportive care programmes as a means of improving patients and their families' well-being. The recognition of the current standpoint of breast cancer in young patients across the continent should shed some light on the importance of this pressing matter.
本综述的目的是整理、总结并批判性地评估拉丁美洲年轻女性局部晚期乳腺癌（LABC）的现有知识。我们在六个部分讨论了最相关的研究结果：1）拉丁美洲年轻女性乳腺癌的流行病学；2）年轻作为预后较差的一个因素；3）该地区年轻女性的局部晚期乳腺癌；4）年轻女性中侵袭性肿瘤行为；5）诊断和治疗的延迟；6）晚期疾病的负担。我们指出，需要投入资源以加强对年轻乳腺癌女性的早期诊断和及时转诊；推动针对该年龄组患病率、生物学特征、治疗结果以及诊断和治疗延迟原因的研究；最后，实施支持性护理计划，以改善患者及其家庭的福祉。认识到整个大陆年轻患者乳腺癌的当前状况，应有助于阐明这一紧迫问题的重要性。
