The First Affiliated Hospital/School of Clinical Medicine of Guangdong Pharmaceutical University, Guangzhou 510006, China.
Department of Chemistry, Quaid-i-Azam University, Islamabad 45320, Pakistan.
Biomed Res Int. 2019 Jan 16;2019:1381989. doi: 10.1155/2019/1381989. eCollection 2019.
Plant diversity is a basic source of food and medicines for the local communities of the Himalayas. Current study was intended to assess polyphenolics content and antioxidant potential in edible wild fruits used as food and to treat various diseases by the inhabitants of Himalayan region of Pakistan. The fruits of 20 plant species were evaluated using standard protocols, whereas information on medicinal uses was gathered through semistructured interviews. Comparatively, and fruits exhibited highest levels of phenolics and flavonols contents (113.55 ± 0.61 mg GAE/100 g and 200.06 ± 1.57 mg RtE/100 g FW, respectively) in acetone extract. Nevertheless, flavonoids were maximum in the water extract of (194.82 ± 3.46 mg RtE/100 g FW). Contrary, fruit depicted significant potential to scavenge DPPH and HO radicals at 94.66 ± 8.89% in acetone extract and 83.54± 9.37% in water extract, while acetone extract of had maximum potential to reduce ferric ions (133.66 ± 15.00 M GAE/100 g FW). Additionally, total antioxidant capacity was highest in the acetone extract of fruit (332.08 ± 21.90 M AAE/100 g FW). The relationships between polyphenolics and antioxidant activity revealed synergistic role of secondary metabolites in the prevention of diseases. Our study revealed that wild fruits consumed by the local communities of Himalayas are rich in health beneficial phytochemicals and hold significant potential to treat chronic diseases, particularly associated with free radicals.
植物多样性是喜马拉雅地区当地社区的食物和药物的基本来源。本研究旨在评估巴基斯坦喜马拉雅地区居民作为食物食用和治疗各种疾病的可食用野生水果的多酚含量和抗氧化潜力。使用标准方案评估了 20 种植物物种的果实，而有关药用用途的信息则通过半结构化访谈收集。相比较而言，和 的果实中丙酮提取物的总酚和类黄酮含量最高（分别为 113.55 ± 0.61 mg GAE/100 g 和 200.06 ± 1.57 mg RtE/100 g FW），而在水中提取物中黄酮类化合物含量最高（194.82 ± 3.46 mg RtE/100 g FW）。相反，果实在丙酮提取物中的 DPPH 和 HO 自由基清除能力最强，为 94.66 ± 8.89%，在水提取物中的清除能力最强，为 83.54± 9.37%，而在丙酮提取物中的铁离子还原能力最强（133.66 ± 15.00 M GAE/100 g FW）。此外，果实的丙酮提取物的总抗氧化能力最高（332.08 ± 21.90 M AAE/100 g FW）。多酚和抗氧化活性之间的关系表明，次生代谢物在预防疾病方面发挥协同作用。我们的研究表明，喜马拉雅地区当地社区食用的野生水果富含有益健康的植物化学物质，具有治疗慢性疾病的巨大潜力，特别是与自由基相关的疾病。
