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动物双歧杆菌乳亚种合成的胞外多糖与肠道上皮细胞中的Toll样受体4相互作用。

Exopolysaccharides synthesized by Bifidobacterium animalis subsp. lactis interact with TLR4 in intestinal epithelial cells.

作者信息

Castro-Bravo Nuria, Margolles Abelardo, Wells Jerry M, Ruas-Madiedo Patricia

机构信息

Microhealth Group, Department of Microbiology and Biochemistry of Dairy Products, Instituto de Productos Lácteos de Asturias - Consejo Superior de Investigaciones Científicas (IPLA-CSIC), Villaviciosa, Asturias, Spain; Host-Microbe Interactomics Group, Animal Science Department, Wageningen University and Research (WUR), Wageningen, the Netherlands.

Microhealth Group, Department of Microbiology and Biochemistry of Dairy Products, Instituto de Productos Lácteos de Asturias - Consejo Superior de Investigaciones Científicas (IPLA-CSIC), Villaviciosa, Asturias, Spain.

出版信息

Anaerobe. 2019 Apr;56:98-101. doi: 10.1016/j.anaerobe.2019.02.014. Epub 2019 Feb 20.

DOI:10.1016/j.anaerobe.2019.02.014
PMID:30794874
Abstract

The toll-like receptors involved in recognition of the exopolysaccharide produced by two isogenic, ropy and non-ropy, Bifidobacterium animalis subsp. lactis strains were investigated. Both strains interact with human embryonic kidney (HEK)-293 cells via TLR2, whereas purified EPSs specifically stimulate TLR4 regardless their molar mass.

摘要

研究了参与识别两株同源的、呈黏液状和非黏液状的动物双歧杆菌乳酸亚种产生的胞外多糖的Toll样受体。两株菌均通过Toll样受体2（TLR2）与人胚肾（HEK）-293细胞相互作用，而纯化的胞外多糖无论其摩尔质量如何，均能特异性刺激Toll样受体4（TLR4）。

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