Queensland Brain Institute, the University of Queensland, St Lucia, QLD 4072, Australia.
Queensland Brain Institute, the University of Queensland, St Lucia, QLD 4072, Australia; Queensland Centre for Mental Health Research, Wacol, QLD 4076, Australia.
Trends Neurosci. 2019 Apr;42(4):293-306. doi: 10.1016/j.tins.2019.01.003. Epub 2019 Feb 19.
Over a billion people worldwide are affected by vitamin D deficiency. Although vitamin D deficiency is associated with impaired cognition, the mechanisms mediating this link are poorly understood. The extracellular matrix (ECM) has now emerged as an important participant of synaptic plasticity and a new hypothesis is that vitamin D may interact with aggregates of the ECM, perineuronal nets (PNNs), to regulate brain plasticity. Dysregulation of PNNs caused by vitamin D deficiency may contribute to the presentation of cognitive deficits. Understanding the molecular mechanisms underpinning the role of vitamin D in brain plasticity and cognition could help identify ways to treat cognitive symptoms in schizophrenia and other neuropsychiatric conditions.
全世界有超过 10 亿人受到维生素 D 缺乏的影响。尽管维生素 D 缺乏与认知障碍有关，但介导这种联系的机制仍不清楚。细胞外基质（ECM）现已成为突触可塑性的重要参与者，一个新的假设是，维生素 D 可能与 ECM 的聚集物、神经周围网络（PNNs）相互作用，以调节大脑的可塑性。维生素 D 缺乏引起的 PNN 失调可能导致认知缺陷的出现。了解维生素 D 在大脑可塑性和认知中的作用的分子机制可能有助于找到治疗精神分裂症和其他神经精神疾病认知症状的方法。
