Xu Qiaoyue, Yao Zhiqiang, Zhou Jie, Zou Wenshuang
Department of Pharmacy, The Affiliated Hospital to Changchun University of Chinese Medicine, Changchun, China.
Department of Anorectal, The Affiliated Hospital to Changchun University of Chinese Medicine, Changchun, China.
Medicine (Baltimore). 2025 May 30;104(22):e42514. doi: 10.1097/MD.0000000000042514.
This study used National Health and Nutrition Examination Survey (NHANES) data to explore the potential association of serum vitamins with major depressive disorder (MDD) among US adults, as well as the potential moderating role of age. This study screened eligible individuals aged ≥ 20 years from NHANES 2005 to 2006 and 2017 to 2018 cycle in the US. Multivariate-adjusted logistic regression models were used to explore the relationship between 5 serum vitamins and MDD. We built 3 models to adjust the potential confounders of 13 factors (age, gender, ethnicity, FIPR, education, hypertension, high cholesterol, diabetes, body mass index, sleep time, dietary quality, physical activity and alcohol consumption) on the outcome. Interaction analysis was performed to explore the moderating effects of age on such association. A total of 4278 participants were included, including 3133 (73.23%) individuals aged < 60 years and 1145 (26.76%) individuals ≥ 60 years. In Age < 60 years group, 229 (7.3%) participants had depressive symptoms. We only observed a negative association between vitamin D (VD) and depressive symptoms (OR = 0.986; 95% CI = 0.973-0.998). Among participants ≥ 60 years old, about 82 (7.71%) of the participation had depressive symptoms. Negative associations with the risk of MDD were found for vitamin A (VA) (OR = 0.212, 95% CI = 0.087-0.512) and VD (OR = 0.853, 95% CI = 0.798-0.912). In addition, we found there were significant interactions between both VA, vitamin E and age on depressive symptom (P = .027, P = .006, respectively). This study investigated the association between serum vitamins and major depression through analysis. The result showed that VD was negatively associated with severe depression in younger patients, while VA and vitamin E were negatively associated with severe depression in older patients. This study provides a new perspective for individualized treatment and intervention of age stratification in severe depression.
本研究利用美国国家健康与营养检查调查（NHANES）数据，探讨血清维生素与美国成年人中重度抑郁症（MDD）之间的潜在关联，以及年龄的潜在调节作用。本研究筛选了2005年至2006年以及2017年至2018年美国NHANES周期中年龄≥20岁的符合条件个体。采用多变量调整逻辑回归模型探讨5种血清维生素与MDD之间的关系。我们构建了3个模型来调整13个因素（年龄、性别、种族、家庭贫困率、教育程度、高血压、高胆固醇、糖尿病、体重指数、睡眠时间、饮食质量、身体活动和饮酒量）对结果的潜在混杂因素。进行交互分析以探讨年龄对这种关联的调节作用。共纳入4278名参与者，其中3133名（73.23%）年龄<60岁，1145名（26.76%）年龄≥60岁。在年龄<60岁组中，229名（7.3%）参与者有抑郁症状。我们仅观察到维生素D（VD）与抑郁症状之间存在负相关（OR = 0.986；95%CI = 0.973 - 0.998）。在年龄≥60岁的参与者中，约82名（7.71%）参与者有抑郁症状。发现维生素A（VA）（OR = 0.212，95%CI = 0.087 - 0.512）和VD（OR = 0.853，95%CI = 0.798 - 0.912）与MDD风险呈负相关。此外，我们发现VA、维生素E与年龄在抑郁症状方面均存在显著交互作用（P分别为0.027、0.006）。本研究通过分析调查了血清维生素与重度抑郁症之间的关联。结果表明，VD与年轻患者的重度抑郁症呈负相关，而VA和维生素E与老年患者的重度抑郁症呈负相关。本研究为重度抑郁症年龄分层的个体化治疗和干预提供了新的视角。
