Bernengo M G, Capella G, Peruccio M, Zina G
Br J Dermatol. 1978 Jun;98(6):655-62. doi: 10.1111/j.1365-2133.1978.tb03584.x.
T and B lymphocyte populations were evaluated in 56 patients with malignant melanoma. Active rosettes (T-Ea) were decreased only in metastatic patients, while the total T population (T-Et) was decreased in all stages. In addition the metastatic patients presented significant decreases in IgD and IgM subpopulations. An increase in null cells was noted in metastatic patients. Regular controls over a period of 2 years showed that T-Ea levels were closely linked to the clinical picture. Patients whose values were constant remained cancer free, while a reduction heralded the appearance of clinical and/or radiological signs of metastasis.
对56例恶性黑色素瘤患者的T淋巴细胞和B淋巴细胞群体进行了评估。活性玫瑰花结（T-Ea）仅在转移性患者中减少，而总T细胞群体（T-Et）在所有阶段均减少。此外，转移性患者的IgD和IgM亚群显著减少。在转移性患者中发现无标记细胞增加。两年期间的常规对照显示，T-Ea水平与临床表现密切相关。T-Ea值保持恒定的患者无癌症，而其降低预示着转移的临床和/或放射学征象出现。
