Bernengo M G, Capella G, de Matteis A, Tovo P A, Zina G
Clin Exp Immunol. 1979 May;36(2):279-84.
The in vitro effect of a calf thymus extract (TP-1) on peripheral blood lymphocytes was evaluated in sixty-six melanoma patients. Twenty out of forty-five stage I and seventeen out of twenty-one stage IIb patients presented depressed T lymphocyte values. A statistically significant increase in E-rosette-forming cells (E-RFC) was observed in seventeen (85%) stage I and twelve (70.5%) stage II patients. In thirteen (65%) stage I and eight (47%) stage II patients E-RFC reached normal values. Our results indicate that the fall of T lymphocytes in the peripheral blood of melanoma patients is often related to an increase in TP-1 sensitive cells which suggests the possibility of a thymic hormone deficiency in these patients.
在66例黑色素瘤患者中评估了小牛胸腺提取物（TP - 1）对外周血淋巴细胞的体外作用。45例I期患者中有20例，21例IIb期患者中有17例T淋巴细胞值降低。在17例（85%）I期和12例（70.5%）II期患者中观察到E花环形成细胞（E - RFC）有统计学意义的增加。在13例（65%）I期和8例（47%）II期患者中E - RFC达到正常值。我们的结果表明，黑色素瘤患者外周血中T淋巴细胞的减少通常与TP - 1敏感细胞的增加有关，这提示这些患者可能存在胸腺激素缺乏。
