Centre for Experimental Medicine & Rheumatology, William Harvey Research Institute, Barts and The London School of Medicine & Dentistry, Queen Mary University of London, UK.
Centre for Experimental Medicine & Rheumatology, William Harvey Research Institute, Barts and The London School of Medicine & Dentistry, Queen Mary University of London, UK.
Curr Opin Immunol. 2019 Apr;57:46-52. doi: 10.1016/j.coi.2019.01.004. Epub 2019 Feb 22.
Tertiary lymphoid organs named also tertiary lymphoid structures (TLS) often occur at sites of autoimmune inflammation, organ transplantation and cancer. Although the mechanisms for their formation/function are not entirely understood, it is known that TLS can display features of active germinal centres supporting the proliferation and differentiation of (auto)-reactive B cells. In this Review, we discuss current knowledge on TLS-associated B cells with particular reference on how within diseased tissues these structures are linked to either deleterious or protective outcomes in patients and the potential for therapeutic targeting of TLS through novel drugs.
三级淋巴器官也称为三级淋巴结构 (TLS)，常发生于自身免疫性炎症、器官移植和癌症部位。尽管其形成/功能的机制尚未完全阐明，但已知 TLS 可表现出活跃的生发中心的特征，支持（自身）反应性 B 细胞的增殖和分化。在这篇综述中，我们讨论了与 TLS 相关的 B 细胞的现有知识，特别提到了在疾病组织中，这些结构如何与患者的有害或保护结果相关，以及通过新型药物靶向 TLS 的治疗潜力。
