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本文引用的文献

1

DBA/2Ha mice as a model of an X-linked immunodeficiency which is defective in the expression of TRF-acceptor site(s) on B lymphocytes.DBA/2Ha小鼠作为一种X连锁免疫缺陷模型，其B淋巴细胞上TRF受体位点的表达存在缺陷。

Immunol Rev. 1982;64:25-55. doi: 10.1111/j.1600-065x.1982.tb00417.x.

2

T cell stimulating growth factors.T细胞刺激生长因子。

Immunol Rev. 1980;51:1-357.

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A severe combined immunodeficiency mutation in the mouse.小鼠中的一种严重联合免疫缺陷突变。

Nature. 1983 Feb 10;301(5900):527-30. doi: 10.1038/301527a0.

4

Mediators from cloned T helper cell lines affect immunoglobulin expression by B cells.来自克隆的辅助性T细胞系的介质影响B细胞的免疫球蛋白表达。

Proc Natl Acad Sci U S A. 1982 Aug;79(15):4756-60. doi: 10.1073/pnas.79.15.4756.

5

Regulation of macrophage populations. I. Preferential induction of Ia-rich peritoneal exudates by immunologic stimuli.巨噬细胞群体的调控。I. 免疫刺激对富含Ia的腹腔渗出物的优先诱导。

J Immunol. 1980 Mar;124(3):1426-32.

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Plasma concentrations of free 5 alpha-androstane-3 alpha, 17 beta-diol and related gonadal steroids during spontaneous and induced sexual maturation in the female rat.

Biol Reprod. 1984 Feb;30(1):105-11. doi: 10.1095/biolreprod30.1.105.

7

B cell maturation factor (BMF): a lymphokine or family of lymphokines promoting the maturation of B lymphocytes.B细胞成熟因子（BMF）：一种促进B淋巴细胞成熟的淋巴因子或一组淋巴因子。

J Immunol. 1984 Jan;132(1):209-22.

8

Gamma-interferon is one of several direct B cell-maturing lymphokines.γ干扰素是几种直接促使B细胞成熟的淋巴因子之一。

Nature. 1984;309(5971):801-4. doi: 10.1038/309801a0.

9

B cell maturation factor: effects on various cell populations.B细胞成熟因子：对各种细胞群体的影响

J Immunol. 1984 Feb;132(2):845-50.

10

Macrophage-activating factor produced by a T cell hybridoma: physiochemical and biosynthetic resemblance to gamma-interferon.一种T细胞杂交瘤产生的巨噬细胞激活因子：与γ干扰素在理化性质和生物合成方面的相似性。

J Immunol. 1983 Aug;131(2):826-32.

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两个影响B细胞对B细胞成熟因子反应的基因座。

Two loci affecting B cell responses to B cell maturation factors.

作者信息

Sidman C L, Marshall J D, Beamer W G, Nadeau J H, Unanue E R

出版信息

J Exp Med. 1986 Jan 1;163(1):116-28. doi: 10.1084/jem.163.1.116.

DOI:10.1084/jem.163.1.116

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2188005/

Abstract

B lymphocytes from DBA/2Ha mice have a genetic defect characterized by a failure to differentiate into antibody-secreting cells in response to a family of lymphokines termed B cell maturation factors (BMFs). By contrast, B cells from DBA/2Ha mice respond normally in PFC assays to the B cell mitogen LPS, and macrophages from these mice are activated by one of the three BMFs. Two loci are responsible for the B cell defect in DBA/2Ha mice. One locus (Bmfr-1) is constitutively expressed throughout life, and maps approximately 13 cM distal to the brown locus on chromosome 4. A second locus (Bmfr-2) becomes active only after sexual maturity and is closely linked to the dilute locus on chromosome 9. At both loci, alleles determining responsiveness to BMFs are dominant over nonresponder alleles. The effect of Bmfr-2 on B cell responsiveness may be related to levels of the steroid sex hormones. DBA/2Ha mice offer a tool for studying the genetic and hormonal regulation of the immune system.

摘要

来自DBA/2Ha小鼠的B淋巴细胞存在一种遗传缺陷，其特征是在对一类称为B细胞成熟因子（BMF）的淋巴因子作出反应时无法分化为抗体分泌细胞。相比之下，来自DBA/2Ha小鼠的B细胞在PFC试验中对B细胞有丝分裂原LPS反应正常，并且这些小鼠的巨噬细胞可被三种BMF之一激活。两个基因座导致DBA/2Ha小鼠的B细胞缺陷。一个基因座（Bmfr-1）在整个生命过程中持续表达，定位在4号染色体上棕色基因座远端约13 cM处。第二个基因座（Bmfr-2）仅在性成熟后才活跃，并且与9号染色体上的稀释基因座紧密连锁。在这两个基因座上，决定对BMF反应性的等位基因对无反应等位基因呈显性。Bmfr-2对B细胞反应性的影响可能与类固醇性激素的水平有关。DBA/2Ha小鼠为研究免疫系统的遗传和激素调节提供了一种工具。