持续性非卧床腹膜透析患者血清及腹膜透析液中甲状腺素结合球蛋白的浓度

Concentrations of thyroxine-binding globulin in sera and peritoneal dialysates in patients on chronic peritoneal ambulatory dialysis.

作者信息

Inaba M, Nishizawa Y, Nishitani H, Miki T, Onishi Y, Mizutani Y, Yamakawa M, Morii H

出版信息

Nephron. 1986;42(1):58-61. doi: 10.1159/000183634.

Abstract

Losses in thyroxine-binding globulin (TBG) in peritoneal dialysate and thyroid function were evaluated in patients undergoing continuous ambulatory peritoneal dialysis (CAPD), in comparison to patients on hemodialysis (HD) without TBG loss in the dialysate. The TBG concentration in the peritoneal dialysate was 0.26 +/- 0.09 microgram/ml (mean +/- SD, n = 24), with a daily loss of 2.47 +/- 0.94 mg. The serum TBG level in CAPD patients was 21.0 +/- 4.71 micrograms/ml (n = 24), which was not significantly different from that in HD patients (20.0 +/- 5.72 micrograms/ml, n = 24) or in healthy Japanese subjects. The serum TBG level correlated positively with the TBG loss and TBG level in the peritoneal dialysate (p less than 0.001). The serum T4 level in CAPD patients (4.93 +/- 1.38 microgram/dl, n = 24) was significantly greater than in HD patients (4.08 +/- 1.30 microgram/dl, n = 24, p less than 0.05).

摘要

与透析液中无甲状腺素结合球蛋白（TBG）丢失的血液透析（HD）患者相比，对接受持续性非卧床腹膜透析（CAPD）的患者腹膜透析液中的TBG丢失及甲状腺功能进行了评估。腹膜透析液中TBG浓度为0.26±0.09微克/毫升（均值±标准差，n = 24），每日丢失量为2.47±0.94毫克。CAPD患者血清TBG水平为21.0±4.71微克/毫升（n = 24），与HD患者（20.0±5.72微克/毫升，n = 24）或健康日本受试者相比无显著差异。血清TBG水平与腹膜透析液中TBG丢失及TBG水平呈正相关（p < 0.001）。CAPD患者血清总甲状腺素（T4）水平（4.93±1.38微克/分升，n = 24）显著高于HD患者（4.08±1.30微克/分升，n = 24，p < 0.05）。