Gardner D F, Mars D R, Thomas R G, Bumrungsup C, Misbin R I
Am J Kidney Dis. 1986 Jun;7(6):471-6. doi: 10.1016/s0272-6386(86)80187-1.
Povidone-iodine is frequently used as an antiseptic in patients on chronic dialysis. In order to determine if the use of povidone-iodine affects thyroid function in these patients, we measured serum iodine and thyroid hormone levels in dialysis patients prior to and following discontinuation of topical povidone-iodine antiseptics. Serum inorganic iodine levels were elevated initially in nearly 90% of the patients (19 on hemodialysis, 12 on continuous ambulatory peritoneal dialysis [CAPD]). Following discontinuation of povidone-iodine, iodine levels over a 3-month period decreased modestly in patients on CAPD (n = 5) and were unchanged in patients on hemodialysis (n = 5). Total and free thyroxine levels were frequently low but did not correlate with protein-bound or inorganic iodine levels and did not change after discontinuation of povidone-iodine. Thyrotropin levels correlated significantly (r = .62, P less than .01) with inorganic iodine levels in patients on hemodialysis, but not for patients on CAPD. We conclude that abnormal thyroid function tests are common in dialysis patients but are not related to iodine retention or to the routine use of topical povidone-iodine-containing antiseptics.
聚维酮碘常用于慢性透析患者的消毒。为了确定使用聚维酮碘是否会影响这些患者的甲状腺功能，我们在透析患者停用局部聚维酮碘消毒剂之前和之后测量了血清碘和甲状腺激素水平。近90%的患者（19例血液透析患者，12例持续性非卧床腹膜透析[CAPD]患者）血清无机碘水平最初升高。停用聚维酮碘后，CAPD患者（n = 5）在3个月内碘水平略有下降，血液透析患者（n = 5）碘水平无变化。总甲状腺素和游离甲状腺素水平经常偏低，但与蛋白结合碘或无机碘水平无关，停用聚维酮碘后也未改变。促甲状腺激素水平与血液透析患者的无机碘水平显著相关（r = 0.62，P < .01），但与CAPD患者无关。我们得出结论，甲状腺功能检查异常在透析患者中很常见，但与碘潴留或常规使用含聚维酮碘的局部消毒剂无关。
