机械力对人牙周膜成纤维细胞骨生成和破骨细胞生成的影响：研究的系统评价
Effects of mechanical forces on osteogenesis and osteoclastogenesis in human periodontal ligament fibroblasts: A systematic review of studies.
作者信息
Li M, Zhang C, Yang Y
机构信息
University of Hong Kong, Hong Kong, China; Stomatological Hospital, Southern Medical University, Guangzhou, China.
Faculty of Dentistry, University of Hong Kong, Hong Kong, China.
出版信息
Bone Joint Res. 2019 Feb 2;8(1):19-31. doi: 10.1302/2046-3758.81.BJR-2018-0060.R1. eCollection 2019 Jan.
OBJECTIVES
Many studies have investigated the mechanism by which mechanical signals are transduced into biological signals that regulate bone homeostasis via periodontal ligament fibroblasts during orthodontic treatment, but the results have not been systematically reviewed. This review aims to do this, considering the parameters of various mechanical loading approaches and their effects on osteogenic and osteoclastogenic properties of periodontal ligament fibroblasts.
METHODS
Specific keywords were used to search electronic databases (EMBASE, PubMed, and Web of Science) for English-language literature published between 1995 and 2017.
RESULTS
A total of 26 studies from the 555 articles obtained via the database search were ultimately included, and four main types of biomechanical approach were identified. Compressive force is characterized by static and continuous application, whereas tensile force is mainly cyclic. Only nine studies investigated the mechanisms by which periodontal ligament fibroblasts transduce mechanical stimulus. The studies provided evidence from mechanical loading regimens that periodontal ligament fibroblasts play a unique and dominant role in the regulation of bone remodelling during orthodontic tooth movement.
CONCLUSION
Evidence from the reviewed studies described the characteristics of periodontal ligament fibroblasts exposed to mechanical force. This is expected to benefit subsequent research into periodontal ligament fibroblasts and to provide indirectly evidence-based insights regarding orthodontic treatment. Further studies should be performed to explore the effects of static tension on cytomechanical properties, better techniques for static compressive force loading, and deeper analysis of underlying regulatory systems.: M. Li, C. Zhang, Y. Yang. Effects of mechanical forces on osteogenesis and osteoclastogenesis in human periodontal ligament fibroblasts: A systematic review of studies. 2019;8:19-31. DOI: 10.1302/2046-3758.81.BJR-2018-0060.R1.
目的
许多研究探讨了正畸治疗期间机械信号通过牙周膜成纤维细胞转导为调节骨稳态的生物信号的机制，但尚未对结果进行系统评价。本综述旨在考虑各种机械加载方法的参数及其对牙周膜成纤维细胞成骨和破骨特性的影响来进行此项工作。
方法
使用特定关键词检索电子数据库（EMBASE、PubMed和Web of Science），以查找1995年至2017年发表的英文文献。
结果
通过数据库检索获得的555篇文章中，最终纳入了26项研究，并确定了四种主要的生物力学方法。压力的特点是静态和持续施加，而拉力主要是周期性的。只有九项研究探讨了牙周膜成纤维细胞转导机械刺激的机制。这些研究从机械加载方案中提供了证据，表明牙周膜成纤维细胞在正畸牙齿移动期间骨重塑的调节中发挥着独特且主导的作用。
结论
综述研究的证据描述了暴露于机械力下的牙周膜成纤维细胞的特征。这有望有益于后续对牙周膜成纤维细胞的研究，并为正畸治疗提供间接的循证见解。应进行进一步研究，以探索静态张力对细胞力学特性的影响、更好的静态压力加载技术以及对潜在调节系统的深入分析。：李M、张C、杨Y。机械力对人牙周膜成纤维细胞成骨和破骨的影响：研究的系统评价。2019；8：19 - 31。DOI：10.1302/2046 - 3758.81.BJR - 2018 - 0060.R1。
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