Department of Colorectal Surgery, The Second Affiliated Hospital of Harbin Medical University, Harbin 150086, China.
Biomolecules. 2024 Nov 20;14(11):1478. doi: 10.3390/biom14111478.
Fibroblasts, which originate from embryonic mesenchymal cells, are the predominant cell type seen in loose connective tissue. As the main components of the internal environment that cells depend on for survival, fibroblasts play an essential role in tissue development, wound healing, and the maintenance of tissue homeostasis. Furthermore, fibroblasts are also involved in several pathological processes, such as fibrosis, cancers, and some inflammatory diseases. In this review, we analyze the latest research progress on fibroblasts, summarize the biological characteristics and physiological functions of fibroblasts, and delve into the role of fibroblasts in disease pathogenesis and explore treatment approaches for fibroblast-related diseases.
成纤维细胞来源于胚胎间充质细胞，是疏松结缔组织中主要的细胞类型。作为细胞赖以生存的内环境的主要组成部分，成纤维细胞在组织发育、伤口愈合和组织内稳态维持中起着至关重要的作用。此外，成纤维细胞还参与了几种病理过程，如纤维化、癌症和一些炎症性疾病。在这篇综述中，我们分析了成纤维细胞的最新研究进展，总结了成纤维细胞的生物学特性和生理功能，并深入探讨了成纤维细胞在疾病发病机制中的作用以及探索成纤维细胞相关疾病的治疗方法。
