高压氧疗法促进二度烧伤愈合：一项在兔子身上的实验研究。
Hyperbaric Oxygen Therapy for Second-Degree Burn Healing: An Experimental Study in Rabbits.
作者信息
Hatibie Mendy J, Islam Andi A, Hatta Mochammad, Moenadjat Yefta, Susilo Rudy H, Rendy Leo
机构信息
In Indonesia, Mendy J. Hatibie, MD, is Head of the Division of Plastic Surgery, University of Sam Ratulangi, Faculty of Medicine, Manado; Andi A. Islam, MD, PhD, is Dean and Professor, Department of Surgery, University of Hasanuddin, Faculty of Medicine, Makassar; Mochammad Hatta, MD, PhD, is Head of the Molecular Biology and Immunology Laboratory, University of Hasanuddin, Faculty of Medicine, Makassar; Yefta Moenadjat, MD, PhD is a Lecturer, Department of Surgery, University of Indonesia, Faculty of Medicine, Jakarta; Rudy H. Susilo, MD, is a general surgeon, Department of Surgery, University of Sam Ratulangi, Faculty of Medicine, Manado; and Leo Rendy, MD, is a general surgeon, Department of Surgery, University of Sam Ratulangi, Faculty of Medicine, Manado. The authors have disclosed no financial relationships related to this article. Submitted August 25, 2018; accepted in revised form October 9, 2018.
出版信息
Adv Skin Wound Care. 2019 Mar;32(3):1-4. doi: 10.1097/01.ASW.0000553110.78375.7b.
BACKGROUND
The wound healing process includes inflammation, proliferation, and remodelling phases, the main features of which are inflammation, neoangiogenesis, and epithelialization. Hyperbaric oxygen therapy (HBOT) is one modality postulated to improve wound healing. The objective of this study was to determine whether HBOT could improve selected features of burn wound healing in an experimental rabbit model.
METHODS
Researchers conducted an experimental study with 36 rabbits given second-degree burns. Subjects were separated into two groups: a control group (n = 18) and an intervention group that was given HBOT at 2.4 atmospheres absolute for 6 days (n = 18). The main outcome measure was wound healing.
RESULTS
Compared with the control group, the HBOT group showed more robust inflammatory cells (P = .025) and epithelialization (P = .024), but no significant difference in angiogenesis (P = .442).
CONCLUSIONS
The authors conclude that HBOT may improve second-degree burn healing by increasing inflammatory cell migration and re-epithelialization.
背景
伤口愈合过程包括炎症、增殖和重塑阶段，其主要特征为炎症、新生血管形成和上皮化。高压氧疗法（HBOT）是一种被认为可改善伤口愈合的治疗方式。本研究的目的是确定高压氧疗法是否能改善实验兔模型中烧伤创面愈合的特定特征。
方法
研究人员对36只遭受二度烧伤的兔子进行了一项实验研究。将实验对象分为两组：对照组（n = 18）和干预组，干预组在2.4个绝对大气压下接受高压氧疗法治疗6天（n = 18）。主要观察指标为伤口愈合情况。
结果
与对照组相比，高压氧疗法组显示出更活跃的炎症细胞（P = 0.025）和上皮化（P = 0.024），但在血管生成方面无显著差异（P = 0.442）。
结论
作者得出结论，高压氧疗法可能通过增加炎症细胞迁移和再上皮化来改善二度烧伤的愈合。
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