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从cDNA序列推导的牛腺苷酸环化酶刺激型G蛋白α亚基的一级结构

Primary structure of the alpha-subunit of bovine adenylate cyclase-stimulating G-protein deduced from the cDNA sequence.

作者信息

Nukada T, Tanabe T, Takahashi H, Noda M, Hirose T, Inayama S, Numa S

出版信息

FEBS Lett. 1986 Jan 20;195(1-2):220-4. doi: 10.1016/0014-5793(86)80164-8.

DOI:10.1016/0014-5793(86)80164-8
PMID:3080331
Abstract

The primary structure of the alpha-subunit of the adenylate cyclase-stimulating G-protein (Gs) has been deduced from the nucleotide sequence of cloned DNA complementary to the bovine cerebral mRNA encoding the polypeptide. Comparison of the amino acid sequences of the alpha-subunits of Gs and transducin reveals that some of the highly conserved regions show sequence homology with elongation factor-Tu and ras p21 proteins and correspond to functional regions of guanine nucleotide-binding proteins.

摘要

通过对编码该多肽的牛脑信使核糖核酸（mRNA）的克隆互补DNA核苷酸序列的推导，得出了刺激腺苷酸环化酶的G蛋白（Gs）α亚基的一级结构。对Gs和转导蛋白α亚基的氨基酸序列进行比较后发现，一些高度保守区域与延伸因子-Tu和ras p21蛋白具有序列同源性，并且与鸟嘌呤核苷酸结合蛋白的功能区域相对应。

相似文献

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Primary structure of the alpha-subunit of bovine adenylate cyclase-stimulating G-protein deduced from the cDNA sequence.从cDNA序列推导的牛腺苷酸环化酶刺激型G蛋白α亚基的一级结构
FEBS Lett. 1986 Jan 20;195(1-2):220-4. doi: 10.1016/0014-5793(86)80164-8.
2
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Molecular cloning of complementary DNA for the alpha subunit of the G protein that stimulates adenylate cyclase.刺激腺苷酸环化酶的G蛋白α亚基互补DNA的分子克隆。
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引用本文的文献

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G protein-mediated inhibition of phosphoinositide metabolism evoked by metabotropic glutamate receptors in frog oocytes.蛙卵母细胞中代谢型谷氨酸受体引发的G蛋白介导的磷酸肌醇代谢抑制作用。
J Physiol. 1994 Jan 1;474(1):35-41. doi: 10.1113/jphysiol.1994.sp020000.
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Human cDNA clones for an alpha subunit of Gi signal-transduction protein.
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Proc Natl Acad Sci U S A. 1986 Oct;83(20):7663-7. doi: 10.1073/pnas.83.20.7663.
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