从cDNA序列推导的牛腺苷酸环化酶刺激型G蛋白α亚基的一级结构
Primary structure of the alpha-subunit of bovine adenylate cyclase-stimulating G-protein deduced from the cDNA sequence.
作者信息
Nukada T, Tanabe T, Takahashi H, Noda M, Hirose T, Inayama S, Numa S
出版信息
FEBS Lett. 1986 Jan 20;195(1-2):220-4. doi: 10.1016/0014-5793(86)80164-8.
The primary structure of the alpha-subunit of the adenylate cyclase-stimulating G-protein (Gs) has been deduced from the nucleotide sequence of cloned DNA complementary to the bovine cerebral mRNA encoding the polypeptide. Comparison of the amino acid sequences of the alpha-subunits of Gs and transducin reveals that some of the highly conserved regions show sequence homology with elongation factor-Tu and ras p21 proteins and correspond to functional regions of guanine nucleotide-binding proteins.
通过对编码该多肽的牛脑信使核糖核酸（mRNA）的克隆互补DNA核苷酸序列的推导，得出了刺激腺苷酸环化酶的G蛋白（Gs）α亚基的一级结构。对Gs和转导蛋白α亚基的氨基酸序列进行比较后发现，一些高度保守区域与延伸因子-Tu和ras p21蛋白具有序列同源性，并且与鸟嘌呤核苷酸结合蛋白的功能区域相对应。
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