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如何消除猪带绦虫病/囊尾蚴病：猪疫苗接种与人体化疗（第二部分）

How to eliminate taeniasis/cysticercosis: porcine vaccination and human chemotherapy (Part 2).

作者信息

Sánchez-Torres Norma Y, Bobadilla Juan R, Laclette Juan P, José Marco V

机构信息

Theoretical Biology Group, Biomedical Research Institute, Universidad Nacional Autónoma de México, Ciudad Universitaria, 04510, CDMX, Mexico.

Department of Immunology, Biomedical Research Institute, Universidad Nacional Autónoma de México, Ciudad Universitaria, 04510, CDMX, Mexico.

出版信息

Theor Biol Med Model. 2019 Feb 26;16(1):4. doi: 10.1186/s12976-019-0100-x.

DOI:10.1186/s12976-019-0100-x
PMID:30803437
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6390339/
Abstract

BACKGROUND

The application of effective vaccines against pig cysticercosis and mass chemotherapy against pig cysticercosis and human taeniasis have shown the feasibility of interrupting the parasite's life cycle in endemic areas.

METHODS

A mathematical model that divides the population into susceptible, infected, and vaccinated individuals is formulated. The model is based upon the life cycle of the parasite. Computer numerical simulation experiments to evaluate the impact of pig vaccination under different vaccination schedules, and combined intervention strategies including pig vaccination and anthelmintic treatment against human taeniasis are carried out.

RESULTS

Vaccination against either pig cysticercosis or against human taeniasis will influence the transmission dynamics not only among vaccinees but also the dynamics of the other hosts as well. When the protective efficacy and/or the coverage rate is less than 100%, different mass interventions like vaccinating the pig population twice in combination with chemotherapeutic treatment against human taeniasis, the elimination of the infection in both pigs and humans can also be achieved.

CONCLUSIONS

Our mathematical model has the potential for planning, and designing effective intervention strategies including both mass vaccination and/or chemotherapeutic treatment to eliminate pig cysticercosis, human taeniasis and human neurocysticercosis. The model can be adapted to any given community with mild, moderate endemicity, or even in hyperendemic regions.

摘要

背景

应用有效的猪囊尾蚴病疫苗以及针对猪囊尾蚴病和人类绦虫病的群体化疗已显示出在流行地区阻断寄生虫生命周期的可行性。

方法

建立一个将人群分为易感者、感染者和接种者的数学模型。该模型基于寄生虫的生命周期。进行计算机数值模拟实验，以评估不同疫苗接种计划下猪疫苗接种的影响，以及包括猪疫苗接种和针对人类绦虫病的驱虫治疗在内的联合干预策略。

结果

针对猪囊尾蚴病或人类绦虫病的疫苗接种不仅会影响接种者之间的传播动态，还会影响其他宿主的动态。当保护效力和/或覆盖率低于100%时，通过不同的群体干预措施，如对猪群进行两次疫苗接种并结合针对人类绦虫病的化疗，也可实现猪和人类感染的消除。

结论

我们的数学模型有潜力用于规划和设计有效的干预策略，包括群体疫苗接种和/或化疗，以消除猪囊尾蚴病、人类绦虫病和人类神经囊尾蚴病。该模型可适用于任何具有轻度、中度流行甚至高度流行的特定社区。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7d55/6390339/1ff79372e7ed/12976_2019_100_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7d55/6390339/f2c57396497c/12976_2019_100_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7d55/6390339/f5c45e4157e9/12976_2019_100_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7d55/6390339/000852d9faf1/12976_2019_100_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7d55/6390339/3338f1db86b2/12976_2019_100_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7d55/6390339/9a8a6a2dd118/12976_2019_100_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7d55/6390339/1ff79372e7ed/12976_2019_100_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7d55/6390339/f2c57396497c/12976_2019_100_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7d55/6390339/f5c45e4157e9/12976_2019_100_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7d55/6390339/000852d9faf1/12976_2019_100_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7d55/6390339/3338f1db86b2/12976_2019_100_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7d55/6390339/9a8a6a2dd118/12976_2019_100_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7d55/6390339/1ff79372e7ed/12976_2019_100_Fig6_HTML.jpg

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