Hazlett L D, Moon M, Berk R S
Infect Immun. 1986 Feb;51(2):687-9. doi: 10.1128/iai.51.2.687-689.1986.
In vivo bacterial adherence of Pseudomonas aeruginosa to the immature ocular epithelium was mediated by a sialic (N-acetylneuraminic) acid (NANA) receptor. Saturation of binding sites on the bacterial surface by NANA prevented attachment of the organism to the epithelial cell membrane receptor. Additionally, a significant number of animals receiving NANA-treated organisms were protected from septicemia and death. In vivo protection studies showed excellent correlation with scanning electron microscopy, in that the number of adherent organisms at the corneal surface decreased dramatically in the presence of NANA. These studies exhibit a strong correlation with clinical cases of human infant ocular infection.
铜绿假单胞菌在体内对未成熟眼上皮的细菌黏附是由唾液酸（N-乙酰神经氨酸，NANA）受体介导的。NANA使细菌表面的结合位点饱和，从而阻止该微生物附着于上皮细胞膜受体。此外，大量接受经NANA处理的微生物的动物免受败血症和死亡。体内保护研究与扫描电子显微镜结果显示出极好的相关性，即角膜表面的黏附微生物数量在NANA存在时显著减少。这些研究与人类婴儿眼部感染的临床病例显示出很强的相关性。
