Hazlett L D, Wells P, Spann B, Berk R S
Invest Ophthalmol Vis Sci. 1980 Jun;19(6):694-7.
Scanning and transmission electron microscopy were used to study the early ocular response to infection by Pseudomonas aeruginosa inoculated under the fused eyelids of immature mice. In the absence of experimental corneal wounding, the organisms produced lysis of the epithelium of the peripheral cornea and conjunctiva and penetrated and lysed the respective stromas as early as 15 min after inoculation. Bacteria were infrequently detected on the ocular surface at 3 hr after infection. At this time, corneal epithelial cells in the vicinity of the inoculation were markedly shrunken.
利用扫描电子显微镜和透射电子显微镜研究了未成熟小鼠融合眼睑下接种铜绿假单胞菌后眼部的早期反应。在没有实验性角膜损伤的情况下，接种后15分钟，这些细菌就会导致周边角膜和结膜上皮细胞溶解，并穿透并溶解相应的基质。感染后3小时，眼表很少检测到细菌。此时，接种部位附近的角膜上皮细胞明显萎缩。
