环磷酰胺对接触致敏中耐受性的逆转作用。先前喂食二硝基氯苯诱导的耐受性。
Reversal by cyclophosphamide of tolerance in contact sensitization. Tolerance induced by prior feeding with DNCB.
作者信息
Polak L, Geleick H, Turk J L
出版信息
Immunology. 1975 May;28(5):939-42.
Abstract
Tolerance to DNCB induced by feeding guinea-pigs with the same hapten has been reversed by a single treatment with cyclophosphamide. This is paralleled by a return of the ability of T cells to proliferate in the draining lymph node following sensitization. Certain quantitative differences between this system and that previously described using intravenous DNBSO3 have been revealed. These may indicate some difference between these two mechanisms of tolerance induction.
摘要
通过给豚鼠喂食相同的半抗原诱导的对二硝基氯苯（DNCB）的耐受性，经环磷酰胺单次处理后得以逆转。这与致敏后引流淋巴结中T细胞增殖能力的恢复相平行。已揭示出该系统与先前使用静脉注射二硝基苯磺酸钠（DNBSO3）所描述的系统之间存在某些定量差异。这些差异可能表明这两种耐受性诱导机制之间存在一些不同。
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本文引用的文献
1
Experimental studies on the pathogenesis of contact eczema in the guinea-pig.
Int Arch Allergy Appl Immunol. 1957;11(1-2):81-100. doi: 10.1159/000228405.
2
Dissociation between lymph node and peripheral reactivity in immunological unresponsiveness to DNCB.
Immunology. 1973 Sep;25(3):451-7.
3
The mechanism of tolerance in contact hypersensitivity to dinitrochlorobenzene in guinea-pigs.
Clin Exp Immunol. 1974 Feb;16(2):203-12.
4
Reversal of immunological tolerance by cyclophosphamide through inhibition of suppressor cell activity.
Nature. 1974 Jun 14;249(458):654-6. doi: 10.1038/249654a0.
5
Investigation of the mechanisms by whick "enhancing" antiserum prevents induction of delayed hypersensitivity to protein antigens in mice.
J Allergy. 1969 Apr;43(4):209-23. doi: 10.1016/0021-8707(69)90064-1.
6
Tolerance reconsidered--a critical survey.
Transplant Proc. 1973 Mar;5(1):7-9.
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