Djafari Jamila, Fernández-Lodeiro Carlos, Fernández-Lodeiro Adrián, Silva Vanessa, Poeta Patrícia, Igrejas Gilberto, Lodeiro Carlos, Capelo José Luis, Fernández-Lodeiro Javier
BIOSCOPE Group, LAQV@REQUIMTE, Chemistry Department, Faculty of Science and Technology, NOVA University Lisbon, Caparica, Portugal.
PROTEOMASS Scientific Society, Rua dos Inventores, Madam Parque, Caparica, Portugal.
Front Chem. 2019 Feb 5;6:677. doi: 10.3389/fchem.2018.00677. eCollection 2018.
In the present work, the synthesis and characterization of silver triangular nanoplates (AgNTs) and their silica coating composites are reported. Engineering control on the surface coating has demonstrated the possibility to modulate the antibacterial effect. Several AgNT-coated nanomaterials, such as PVP (Polyvinylpyrrolidone) and MHA (16-mercaptohexadecanoic acid) as a stable organic coating system as well as uniform silica coating (≈5 nm) of AgNTs, have been prepared and fully characterized. The antibacterial properties of the systems reported, organic (MHA) and inorganic (amine and carboxylic terminated SiO) coating nanocomposites, have been tested on Gram-positive and Gram-negative bacteria strains. We observed that the AgNTs' organic coating improved antimicrobial properties when compared to other spherical silver colloids found in the literature. We have also found that thick inorganic silica coating decreases the antimicrobial effect, but does not cancel it. In addition, the effect of surface charge in AgNTs@Si seems to play a crucial role toward ATCC 25923 bacteria, obtaining MIC/MBC values compared to the AgNTs with an organic coating.
在本工作中，报道了三角形银纳米片（AgNTs）及其二氧化硅包覆复合材料的合成与表征。对表面涂层的工程控制已证明调节抗菌效果的可能性。已制备并充分表征了几种AgNT包覆的纳米材料，如作为稳定有机涂层体系的PVP（聚乙烯吡咯烷酮）和MHA（16-巯基十六烷酸）以及AgNTs的均匀二氧化硅涂层（≈5nm）。所报道的体系，即有机（MHA）和无机（胺基和羧基封端的SiO）包覆纳米复合材料的抗菌性能，已在革兰氏阳性和革兰氏阴性细菌菌株上进行了测试。我们观察到，与文献中发现的其他球形银胶体相比，AgNTs的有机涂层提高了抗菌性能。我们还发现，厚的无机二氧化硅涂层会降低抗菌效果，但不会消除它。此外，AgNTs@Si中的表面电荷效应似乎对ATCC 25923细菌起着关键作用，与具有有机涂层的AgNTs相比，获得了最低抑菌浓度/最低杀菌浓度值。
