Department of Medicine, University of Calgary, Calgary, Alberta, Canada.
Alberta Health Services, Calgary, Alberta, Canada.
Nutr Clin Pract. 2020 Feb;35(1):119-125. doi: 10.1002/ncp.10265. Epub 2019 Feb 26.
To explore the influence of nourishment state measured by various nutrition assessment tools (NATs) on health-related quality of life (HRQoL) in a pretransplant population with cirrhosis.
We collected demographic, nutrition assessment, and disease specific data on 81 patients. HRQoL was measured with the Short-Form 36 and divided into 8 subscales. Significant relationships between NATs and HRQoL were examined using independent sample t-tests, χ analyses, correlations, and multiple and logistic regression adjusted for age and gender.
Study mean age was 54.2 years (SD 10.4 years), and 57% were male. Subjective Global Assessment (SGA) was significantly related to all HRQoL subscales, except bodily pain and mental health. In the adjusted regression models, general health, vitality, and social functioning were all significantly lower in patients with poorer nutrition status measured using SGA (adjusted R = 11%, β = -0.34, p < 0.01; adjusted R = 8%, β = -0.27, P < 0.05; and adjusted R = 12%, β = -0.38, P < 0.01, Q4 respectively). Physical functioning improved as hand grip strength increased (adjusted R = 20%, β = 0.36, P < 0.01). MELDNa demonstrated a significant negative relationship with role-emotional (adjusted R = 3%, β = 0.25, P < 0.05), and mid-arm circumference did not demonstrate any significant relationships with HRQoL.
Malnutrition assessed by SGA is associated with lower HRQoL in patients with cirrhosis. Future research should identify if nutrition interventions can effectively improve HRQoL in cirrhosis patients.
探讨用不同营养评估工具（NATs）评估营养状态对肝硬化移植前人群健康相关生活质量（HRQoL）的影响。
我们收集了 81 名患者的人口统计学、营养评估和疾病特定数据。使用简短形式 36 项量表（SF-36）测量 HRQoL，并将其分为 8 个亚量表。使用独立样本 t 检验、卡方检验、相关性以及多元和逻辑回归分析，调整年龄和性别后，分析 NATs 与 HRQoL 之间的显著关系。
研究的平均年龄为 54.2 岁（标准差 10.4 岁），57%为男性。主观全面评估（SGA）与除躯体疼痛和心理健康外的所有 HRQoL 亚量表显著相关。在调整后的回归模型中，SGA 评估的营养状况较差的患者，一般健康、活力和社会功能均显著降低（调整后的 R2 = 11%，β = -0.34，P < 0.01；调整后的 R2 = 8%，β = -0.27，P < 0.05；调整后的 R2 = 12%，β = -0.38，P < 0.01，Q4 分别）。握力增加时，身体功能改善（调整后的 R2 = 20%，β = 0.36，P < 0.01）。MELDNa 与角色情感呈显著负相关（调整后的 R2 = 3%，β = 0.25，P < 0.05），而上臂中部周长与 HRQoL 无显著关系。
SGA 评估的营养不良与肝硬化患者的 HRQoL 较低相关。未来的研究应确定营养干预是否能有效改善肝硬化患者的 HRQoL。
