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血流介导皮肤荧光技术揭示年龄对 1 型糖尿病患者微循环和代谢调节的显著影响。

Flow Mediated Skin Fluorescence technique reveals remarkable effect of age on microcirculation and metabolic regulation in type 1 diabetes.

机构信息

Angionica Ltd., Lodz, Poland.

Department of Internal Diseases and Diabetology, Medical University of Lodz, Lodz, Poland.

出版信息

Microvasc Res. 2019 Jul;124:19-24. doi: 10.1016/j.mvr.2019.02.005. Epub 2019 Feb 23.

DOI:10.1016/j.mvr.2019.02.005
PMID:30807771
Abstract

STUDY DESCRIPTION

Flow Mediated Skin Fluorescence (FMSF) is a novel technique for non-invasive evaluation of the microcirculation and metabolic regulation. This study describes the diagnostic potential of FMSF for type 1 diabetes (DM1).

STUDY POPULATION

All study participants, in both the control (n = 31) and DM1 (n = 40) groups, were between the ages of 30-49 y. The patients in the DM1 group had all been suffering from diabetes for at least 10 y.

RESULTS

The parameters HR, HR and MR inversely correlate with age and BMI. An unidentified compensatory effect was observed among the younger members of the DM1 group. The majority of DM1 patients with HR < 8% showed signs of dysfunctional metabolic regulation.

CONCLUSION

FMSF appears to be an extremely useful technique for monitoring diabetic patients over time, enabling early diagnosis of potentially dysfunctional microcirculation and metabolic regulation.

摘要

研究描述

血流介导的皮肤荧光(FMSF)是一种用于评估微循环和代谢调节的非侵入性新技术。本研究描述了 FMSF 在 1 型糖尿病(DM1)中的诊断潜力。

研究人群

所有研究参与者,包括对照组(n=31)和 DM1 组(n=40),年龄均在 30-49 岁之间。DM1 组的患者均患有糖尿病至少 10 年。

结果

参数 HR、HR 和 MR 与年龄和 BMI 呈负相关。在 DM1 组较年轻的成员中观察到一种未明的代偿效应。大多数 HR<8%的 DM1 患者表现出代谢调节功能障碍的迹象。

结论

FMSF 似乎是一种非常有用的技术,可用于随时间监测糖尿病患者,有助于早期诊断潜在的功能障碍的微循环和代谢调节。

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