Medical Center, Saint Family Hospital, Lodz, Poland.
Department of Internal Medicine and Geronto-Cardiology, Medical Centre for Postgraduate Education, Warsaw, Poland.
Vasc Health Risk Manag. 2022 Sep 6;18:711-719. doi: 10.2147/VHRM.S371468. eCollection 2022.
The pathophysiology of chronic fatigue associated with post-COVID syndrome is not well recognized. It is assumed that this condition is partly due to vascular dysfunction developed during an acute phase of infection. There is great demand for a diagnostic tool that is able to clinically assess post-COVID syndrome and monitor the rehabilitation process.
The Flow Mediated Skin Fluorescence (FMSF) technique appears uniquely suitable for the analysis of basal microcirculatory oscillations and reactive hyperemia induced by transient ischemia. The FMSF was used to measure vascular circulation in 45 patients with post-COVID syndrome. The results were compared with those for a group of 26 amateur runners before and after high-intensity exercise as well as for a control group of 32 healthy age-matched individuals.
Based on the observed changes in the NOI (Normoxia Oscillatory Index) and RHR (Reactive Hyperemia Response) parameters measured with the FMSF technique, it was found that chronic fatigue associated with post-COVID syndrome is comparable with transient fatigue caused by high-intensity exercise in terms of vascular effects, which are associated with vascular stress in the macrocirculation and microcirculation. Acute and chronic fatigue symptomatology shared similarly altered changes in the NOI and RHR parameters and both can be linked to calcium homeostasis modification.
The NOI and RHR parameters measured with the FMSF technique can be used for non-invasive clinical assessment of post-COVID syndrome as well as for monitoring the rehabilitation process.
与新冠后综合征相关的慢性疲劳的病理生理学尚未得到充分认识。据推测，这种情况部分是由于感染急性期发生的血管功能障碍引起的。因此，非常需要一种能够对新冠后综合征进行临床评估并监测康复过程的诊断工具。
血流介导的皮肤荧光（Flow Mediated Skin Fluorescence，FMSF）技术似乎非常适合分析基础微循环的震荡和短暂缺血引起的反应性充血。使用 FMSF 技术测量了 45 名新冠后综合征患者的血管循环。将结果与 26 名业余跑步者在高强度运动前后的结果以及 32 名健康同龄对照组进行比较。
根据 FMSF 技术测量的 NOI（Normoxia Oscillatory Index，正常氧振荡指数）和 RHR（Reactive Hyperemia Response，反应性充血反应）参数的观察变化，发现与高强度运动引起的短暂疲劳相比，与新冠后综合征相关的慢性疲劳在血管效应方面具有可比性，这与大循环和微循环中的血管应激有关。急性和慢性疲劳症状表现出相似的 NOI 和 RHR 参数变化，两者都可以与钙稳态的改变相关。
使用 FMSF 技术测量的 NOI 和 RHR 参数可用于对新冠后综合征进行非侵入性的临床评估，并监测康复过程。
