Aoki N
Surg Neurol. 1986 Mar;25(3):279-82. doi: 10.1016/0090-3019(86)90240-5.
Two cancer patients are reported, who presented with altered consciousness 2 and 3 months, respectively, after the administration of 5-fluorouracil derivatives, and progressed to a state of akinetic mutism. At first a presumptive diagnosis of metastatic brain tumor was made. However, the result of a cerebrospinal fluid cytology for malignancy was negative, and computed tomography (CT) scanning revealed diffuse decreased attenuation of the cerebral white matter, indicative of leukoencephalopathy, without association of mass lesion. Upon discontinuing the drugs, both patients made significant recovery and the decreased attenuation on the CT also disappeared. The significance of the early diagnosis of this pathology is emphasized.
报告了两名癌症患者，他们分别在使用5-氟尿嘧啶衍生物后2个月和3个月出现意识改变，并进展为运动不能性缄默状态。起初做出了转移性脑肿瘤的初步诊断。然而，脑脊液恶性肿瘤细胞学检查结果为阴性，计算机断层扫描（CT）显示脑白质弥漫性衰减降低，提示白质脑病，无占位性病变。停用药物后，两名患者均有显著恢复，CT上的衰减降低也消失了。强调了这种病理早期诊断的重要性。
