Matsumoto S, Nishizawa S, Murakami M, Noma S, Sano A, Kuroda Y
Department of Nuclear Medicine, Faculty of Medicine, Kyoto University, Japan.
Neuroradiology. 1995 Nov;37(8):649-52. doi: 10.1007/BF00593382.
Carmofur, a derivative of 5-fluorouracil, has recently been noted to have an infrequent but serious association with leukoencephalopathy. To our knowledge, there has been no report of early MRI findings in this leukoencephalopathy. We describe a case in which diffuse high signal intensity of the entire cerebral white matter, including the corpus callosum, was seen on T2-weighted magnetic resonance images. Although similar findings can be seen in many other diseases, carmofur-induced leukoencephalopathy should be suspected in a patient treated with carmofur. It is important to know the clinical and MRI characteristics of this condition, for early diagnosis and better prognosis.
卡莫氟是5-氟尿嘧啶的衍生物，最近发现它与白质脑病存在一种罕见但严重的关联。据我们所知，尚未有关于这种白质脑病早期MRI表现的报道。我们描述了一例在T2加权磁共振图像上可见包括胼胝体在内的整个脑白质弥漫性高信号强度的病例。尽管在许多其他疾病中也能看到类似表现，但对于接受卡莫氟治疗的患者，应怀疑为卡莫氟诱导的白质脑病。了解这种疾病的临床和MRI特征对于早期诊断和改善预后很重要。
