HIV 感染和埃塞俄比亚结核病患者中未知的 HIV 状况：系统评价和荟萃分析。

HIV infection and unknown HIV status among tuberculosis patients in Ethiopia: a systematic review and meta-analysis.

机构信息

Department of Paediatrics and Child Health Nursing, School of Nursing.

Department of Clinical Chemistry, School of Biomedical and Laboratory Sciences.

出版信息

Int J Tuberc Lung Dis. 2019 Feb 1;23(2):187-194. doi: 10.5588/ijtld.18.0363.

DOI:10.5588/ijtld.18.0363

PMID:30808451

Abstract

BACKGROUND AND OBJECTIVE

Each case of human immunodeficiency virus (HIV) infection worsens the global HIV situation, leads to the failure to achieve tuberculosis (TB) control targets worldwide, and impacts on the use of health service resources. We determined the prevalence of HIV infection among TB patients and the proportion of TB patients with unknown HIV status in Ethiopia.

METHODS

We searched PubMed, EMBASE, Google Scholar and Web of Science electronic databases. Heterogeneity of the included studies was checked using the ² statistic and publication bias was assessed using funnel plots and Egger's regression statistical test. We employed a random-effects model to determine the pooled prevalence of HIV infection and unknown HIV status. A sensitivity analysis was also conducted to examine the effect of possible outliers on the overall estimate.

RESULTS

The prevalence of HIV infection among TB patients and the proportion of TB patients with unknown HIV status was respectively 23.4% (95%CI 19.6-27.2) and 6.4% (95%CI 1.7-11.0). Based on geographical location, the prevalence of HIV infection was 31.4% (95%CI 19.2-43.6) in Amhara Region, 23.2% (95%CI 9.9-36.5) in Oromia, 20.9% (95%CI 17.8-24.0) in Addis Ababa and 16.5% (95%CI 12.0-21.0) in Southern Nations, Nationalities and Peoples' Region (SNNPR).

CONCLUSION

In Ethiopia, almost one in four TB patients is infected with HIV. Given the epidemiological variation of Ethiopia, responsive, integrated sustainable programmes for HIV and TB are essential to minimise the epidemics of HIV infection and TB

摘要

背景和目的

每一例人类免疫缺陷病毒（HIV）感染都会使全球 HIV 形势恶化，导致全球无法实现结核病（TB）控制目标，并影响卫生服务资源的利用。我们确定了在埃塞俄比亚，TB 患者中 HIV 感染的流行率以及未知 HIV 状态的 TB 患者的比例。

方法

我们检索了 PubMed、EMBASE、Google Scholar 和 Web of Science 电子数据库。使用 ² 统计量检查纳入研究的异质性，并使用漏斗图和 Egger 回归统计检验评估发表偏倚。我们采用随机效应模型来确定 HIV 感染和未知 HIV 状态的总体流行率。还进行了敏感性分析，以检查可能的异常值对总体估计的影响。

结果

TB 患者中 HIV 感染的流行率和未知 HIV 状态的 TB 患者比例分别为 23.4%（95%CI 19.6-27.2）和 6.4%（95%CI 1.7-11.0）。根据地理位置，阿姆哈拉地区 HIV 感染的流行率为 31.4%（95%CI 19.2-43.6），奥罗米亚地区为 23.2%（95%CI 9.9-36.5），亚的斯亚贝巴为 20.9%（95%CI 17.8-24.0），南部地区为 16.5%（95%CI 12.0-21.0）。民族和人民地区（SNNPR）。