University of Oklahoma Health Sciences Center, Department of Internal Medicine, Division of Rheumatology, Immunology, and Allergy, Oklahoma City, OK, USA; Oklahoma Medical Research Foundation, Arthritis & Clinical Immunology Program, Oklahoma City, OK, USA.
Osteoarthritis Cartilage. 2019 Mar;27(3):371-377. doi: 10.1016/j.joca.2018.10.004. Epub 2018 Oct 25.
This review was designed to identify highlights of the osteoarthritis (OA) genetics and epigenetics literature published between April 2017 and January 2018.
A Pubmed literature search was conducted using the keywords 'osteoarthritis' and each of the following: 'genomic', 'genetic', 'epigenomic', 'epigenetic', 'histone', 'noncoding RNA', 'miRNA', 'lncRNA', 'DNA methylation', 'DNA hydroxymethylation', 'DNMT', and 'TET'. The dates of publication were restricted to 4/1/2017-1/15/2018. Results were compared to the same search terms limited to 4/1/2016-1/15/2017.
Virtually all search term combinations demonstrated a decrease in papers published this year compared to last, with epigenetic and miRNA/lncRNA research being stable. Despite this, numerous advances were made this year, including the second large genome-wide association study (GWAS) study of hand OA, a new twin study of hip and knee OA concordance, an extensive study of GDF5 evolution, analyses of the contribution of Dnmt3a to OA, a description of DNA methylation in a nonhuman primate model of OA, and an integrated, multi-omics analysis of DNA methylation, mRNA, and protein expression in human OA samples, among others. A variety of micro- and a few circular-RNA studies were also published, highlighting the importance of noncoding RNA in both the pathogenesis and potential treatment of OA.
Although publications have decreased slightly in the last year, genetics and epigenetics continue to be a topic of substantial research in OA, and considerable progress continues to be made in the field.
本综述旨在确定 2017 年 4 月至 2018 年 1 月期间发表的骨关节炎（OA）遗传学和表观遗传学文献的要点。
使用关键词“骨关节炎”和以下各项进行 Pubmed 文献搜索：“基因组”、“遗传”、“表观基因组”、“表观遗传”、“组蛋白”、“非编码 RNA”、“miRNA”、“lncRNA”、“DNA 甲基化”、“DNA 羟甲基化”、“DNMT”和“TET”。出版日期限于 2017 年 4 月 1 日至 2018 年 1 月 15 日。将结果与相同的搜索条件限制在 2016 年 4 月 1 日至 2017 年 1 月 15 日进行比较。
几乎所有搜索词组合都表明今年发表的论文数量比去年减少，而表观遗传学和 miRNA/lncRNA 研究则保持稳定。尽管如此，今年还是取得了许多进展，包括手部 OA 的第二项大型全基因组关联研究（GWAS）研究、髋关节和膝关节 OA 一致性的新双胞胎研究、对 GDF5 进化的广泛研究、分析 Dnmt3a 对 OA 的贡献、在 OA 非人类灵长类动物模型中描述 DNA 甲基化，以及对人类 OA 样本中 DNA 甲基化、mRNA 和蛋白质表达的综合、多组学分析等。还发表了一些 micro 和少数 circular-RNA 研究，强调了非编码 RNA 在 OA 的发病机制和潜在治疗中的重要性。
尽管去年的出版物略有减少，但遗传学和表观遗传学仍然是 OA 研究的一个重要课题，该领域继续取得相当大的进展。
