Department of Cardiology, Rigshospitalet, Faculty of Health and Medical Sciences, University of Copenhagen, Blegdamsvej 9, 2100 Copenhagen, Denmark.
Department of Radiology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
Eur Heart J Cardiovasc Imaging. 2019 Aug 1;20(8):939-948. doi: 10.1093/ehjci/jez012.
Accurate assessment of aortic dimensions can be achieved using contrast-enhanced computed tomography. The aim of this study was to define normal values and determinants of aortic dimensions throughout multiple key anatomical landmarks of the aorta in healthy individuals from the Copenhagen General Population Study.
The study group consisted of 902 healthy subjects selected from 3000 adults undergoing cardiovascular thoracic and abdominal computed tomography-angiography (CTA), where systematic measurements of aortic dimensions were performed retrospectively. Individuals included were without any of the following predefined cardiovascular risk factors: (i) self-reported angina pectoris; (ii) hypertension; (iii) hypercholesterolaemia; (iv) taking cardiovascular prescribed medication including diuretics, statins, or aspirin; (v) overweight (defined as body mass index ≥30 kg/m2); (vi) diabetes mellitus (self-reported or blood glucose >8 mmol/L); and (vii) chronic obstructive pulmonary disease. Maximal aortic diameters were measured at seven aortic regions: sinuses of Valsalva, sinotubular junction, ascending aorta, mid-descending aorta, abdominal aorta at the diaphragm, abdominal aorta at the coeliac trunk, and infrarenal abdominal aorta. Median age was 52 years, and 396 (40%) were men. Men had significantly larger aortic diameters at all levels compared with women (P < 0.001). Multivariable analysis revealed that sex, age, and body surface area were associated with increasing aortic dimensions.
Normal values of maximal aortic dimensions at key aortic anatomical locations by contrast-enhanced CTA have been defined. Age, sex, and body surface area were significantly associated with these measures at all levels of aorta. Aortic dimensions follow an almost identical pattern throughout the vessel regardless of sex.
对比增强 CT 可准确评估主动脉尺寸。本研究旨在定义健康个体在哥本哈根普通人群研究中主动脉多个关键解剖学标志处的主动脉尺寸的正常参考值和决定因素。
该研究组由 3000 名接受心血管胸腹部 CT 血管造影（CTA）的成年人中选择的 902 名健康受试者组成，对其进行了系统的主动脉尺寸测量。入选者均无以下预先定义的心血管危险因素：（i）自述心绞痛；（ii）高血压；（iii）高胆固醇血症；（iv）服用心血管处方药，包括利尿剂、他汀类药物或阿司匹林；（v）超重（定义为 BMI≥30kg/m2）；（vi）糖尿病（自述或血糖>8mmol/L）；（vii）慢性阻塞性肺疾病。在七个主动脉区域测量最大主动脉直径：主动脉窦，窦管交界，升主动脉，降主动脉中段，膈肌处腹主动脉，腹腔干处腹主动脉和肾下腹主动脉。中位年龄为 52 岁，其中 396 名（40%）为男性。与女性相比，男性在所有层面的主动脉直径均显著更大（P<0.001）。多变量分析显示，性别、年龄和体表面积与主动脉尺寸的增加相关。
通过对比增强 CTA 定义了关键主动脉解剖部位的最大主动脉尺寸的正常参考值。年龄、性别和体表面积与所有层面的这些测量值显著相关。无论性别如何，主动脉尺寸在整个血管中呈现出几乎相同的模式。
