Wellcome Trust Asia Programme-Oxford University Clinical Research Unit, 78 Giai Phong, Dong Da, Ha Noi, Viet Nam.
Wellcome Trust Asia Programme-Oxford University Clinical Research Unit, 764 Vo Van Kiet, Ward 1, District 5, Ho Chi Minh, Viet Nam.
Trans R Soc Trop Med Hyg. 2019 Jun 1;113(6):341-350. doi: 10.1093/trstmh/trz004.
Streptococcus suis is a zoonotic disease mainly affecting men of working age and can result in death or long-term sequelae, including severe hearing loss and vestibular dysfunction. We aimed to quantify the burden of disease and economic impact of this infection in Viet Nam.
The annual disease incidence for the period 2011-2014 was estimated based on surveillance data using a multiple imputation approach. We calculated disease burden in disability-adjusted life years (DALYs) and economic costs using an incidence-based approach from a patient's perspective and including direct and indirect impacts of S. suis infection and its long-term sequelae.
The estimated annual incidence rate was 0.318, 0.324, 0.255 and 0.249 cases per 100 000 population in 2011, 2012, 2013 and 2014, respectively. The corresponding DALYs lost were 1832, 1866, 1467 and 1437. The mean direct cost per episode was US$1635 (95% confidence interval 1352-1923). The annual direct cost was US$370 000-500 000 and the indirect cost was US$2.27-2.88 million in this time period.
This study showed a large disease burden and high economic impact of S. suis infection and provides important data for disease monitoring and control.
猪链球菌病是一种主要影响劳动年龄男性的人畜共患病，可导致死亡或长期后遗症，包括严重听力损失和前庭功能障碍。本研究旨在量化越南猪链球菌感染的疾病负担和经济影响。
采用多重插补法，基于 2011-2014 年的监测数据估计年度疾病发病率。我们采用基于发病率的方法从患者角度计算疾病负担（以伤残调整生命年衡量）和经济成本，包括猪链球菌感染及其长期后遗症的直接和间接影响。
2011 年、2012 年、2013 年和 2014 年的估计年发病率分别为每 100000 人口 0.318、0.324、0.255 和 0.249 例。相应的伤残调整生命年损失分别为 1832、1866、1467 和 1437。每例的平均直接费用为 1635 美元（95%置信区间 1352-1923）。在此期间，每年的直接费用为 37 万至 50 万美元，间接费用为 227 万至 288 万美元。
本研究表明猪链球菌感染的疾病负担大且经济影响高，为疾病监测和控制提供了重要数据。
