a Department of Psychiatry , University of North Carolina at Chapel Hill , Chapel Hill , NC , USA.
b Department of Genetics , University of North Carolina at Chapel Hill , Chapel Hill , NC , USA.
Int Rev Psychiatry. 2019 May;31(3):229-236. doi: 10.1080/09540261.2018.1551191. Epub 2019 Feb 27.
The International Postpartum depression: Action towards Causes and Treatment (PACT) Consortium was founded with the overarching goal of creating an international perinatal psychiatry consortium to conduct novel investigations with large sample sizes to understand the genetic signature of perinatal mood disorders. PACT uses a collaborative and team science approach that includes investigators across 19 institutions and seven continents. The large sample sizes allow for statistically rigorous analyses to investigate perinatal psychiatric disorders, with an initial focus on postpartum depression (PPD). Our current aims are to identify clinical sub-types of PPD that contribute diagnostic heterogeneity, and to elucidate the genetic basis of PPD by conducting the first large genome-wide association study of PPD. To accomplish the latter aim, we are partnering with the Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium. To date, our consortium members have recruited 17,912 participants and 11,344 participants have been identified using the mobile app, of which 8,432 are PPD cases. Ultimately, we hope this approach will improve detection, diagnosis, and treatment of women who suffer from perinatal psychiatric disorders.
病因与治疗行动（PACT）联合会的成立，旨在建立一个国际性的围产期精神病学联合会，以开展具有大样本量的新研究，了解围产期情绪障碍的遗传特征。PACT 采用合作和团队科学的方法，包括来自 19 个机构和七大洲的研究人员。大样本量允许进行统计学上严格的分析，以研究围产期精神疾病，最初的重点是产后抑郁症（PPD）。我们目前的目标是确定导致诊断异质性的 PPD 临床亚型，并通过对 PPD 进行首次全基因组关联研究来阐明 PPD 的遗传基础。为了实现后者的目标，我们正在与精神疾病基因组学联合会的重度抑郁症工作组合作。迄今为止，我们的联合会成员已经招募了 17912 名参与者，其中 11344 名参与者通过移动应用程序确定，其中 8432 名是 PPD 病例。最终，我们希望这种方法能够提高对患有围产期精神疾病的女性的检测、诊断和治疗水平。
