Department of Humanities and Sciences, University of California-Los Angeles, Los Angeles, California, United States of America.
Environmental Monitoring Division, City of Los Angeles, Playa Del Rey, California, United States of America.
PLoS One. 2019 Feb 27;14(2):e0212938. doi: 10.1371/journal.pone.0212938. eCollection 2019.
The increased mortality rate among the Acoli people of northern Uganda is anecdotally blamed on excessive consumption of cheap and widely available sachet-packaged alcohol in the region. In this paper, we quantify this perceived association by determining statistically the health risks associated with ingesting 20 heavy metals in 17 popular spirits products consumed in Acoli. Thirteen of these products were industrially packaged in sachets (locally known as 'sachet,' waragi, arege or moo lyec) and four were locally produced Lira-Lira spirits from Bolo, Awere and Teso Bar in the region and Nsambya in southern Uganda. A Scottish whisky purchased in San Diego (USA) was our reference. Risk assessment was performed according to standardized protocols developed by the United States Environmental Protection Agency (US EPA). Our results show that a strong correlation indeed exists between health risks and ingestion of spirits in Acoli. At >2.5 sachets/day for 240 day/year over a lifetime for example, the risk of developing cancer due to exposure to As, Pb and Cr alone is 1 in 102,041. This estimate excludes ethanol, a known carcinogen, and 17 heavy metals also studied due to lack of their cancer slope factors. The primary non-cancer related health risk factor in all samples tested is ethanol with unacceptably high health index of four. The Lira-Lira spirits, with 100-6000% copper above the US EPA limit for intake by oral ingestion in water, would be the 'cleanest' without copper and at par with the Scottish whisky. Collectively, we find that no amount of alcohol consumed in Acoli is safe. Preventive measures are therefore recommended to reduce mortality in Acoli in particular, and in Uganda in general. These measures should include public education, better public policies, creating productive economic activities other than brewing alcohol, and social activities that engage people away from drinking.
乌干达北部 Acoli 人的死亡率上升,据说是因为该地区人们过度消费廉价且广泛供应的袋装酒精。在本文中,我们通过确定在 Acoli 地区消费的 17 种流行烈酒中 20 种重金属的相关健康风险,量化了这种感知到的关联。其中 13 种产品是用塑料袋包装的(当地称为“sachet”、waragi、arege 或 moo lyec),4 种是当地生产的来自该地区的 Bolo、Awere 和 Teso Bar 的 Lira-Lira 烈酒以及乌干达南部的 Nsambya。我们还选择了从美国圣地亚哥购买的苏格兰威士忌作为参考。风险评估是根据美国环境保护署 (US EPA) 制定的标准化协议进行的。我们的结果表明,Acoli 地区人们的健康风险与饮酒之间确实存在很强的相关性。例如,终生每年 240 天,每天摄入超过 2.5 袋 sachet 的烈酒,仅因接触 As、Pb 和 Cr 而患癌症的风险为 1 比 102041。这个估计不包括乙醇,它是一种已知的致癌物质,以及 17 种重金属,由于缺乏其癌症斜率因子,也在研究之列。在所有测试的样本中,主要的非癌症相关健康风险因素是乙醇,其健康指数高达四,是不可接受的。在所有测试的样本中,由于摄入水中的铜含量超过美国环保署规定的上限 100-6000%,Lira-Lira 烈酒是“最干净”的,与苏格兰威士忌相当。总的来说,我们发现 Acoli 地区人们摄入任何数量的酒精都不安全。因此,建议采取预防措施,特别是降低 Acoli 地区的死亡率,以及乌干达的总体死亡率。这些措施应包括公众教育、更好的公共政策、创造除酿造酒精以外的生产性经济活动,以及让人们远离饮酒的社交活动。