Rudling M J, Ståhle L, Peterson C O, Skoog L
Br Med J (Clin Res Ed). 1986 Mar 1;292(6520):580-2. doi: 10.1136/bmj.292.6520.580.
The content of low density lipoprotein (LDL) receptors in tissue from primary breast cancers was determined and its prognostic information compared with that of variables of established prognostic importance. Frozen tumour specimens were selected, and tissue from 72 patients (32 of whom had died) were studied. The LDL receptor content showed an inverse correlation with the survival time. Analysis by a multivariate statistical method showed that the presence of axillary metastasis, content of receptors for oestrogen and LDL, diameter of the tumour, and DNA pattern were all of prognostic value with regard to patient survival. Improved methods of predicting survival time in patients with breast cancer may be of value in the choice of treatment for individual patients.
测定原发性乳腺癌组织中低密度脂蛋白（LDL）受体的含量，并将其预后信息与已确定具有预后重要性的变量的预后信息进行比较。选择冷冻肿瘤标本，对72例患者（其中32例已死亡）的组织进行研究。LDL受体含量与生存时间呈负相关。多变量统计方法分析表明，腋窝转移的存在、雌激素和LDL受体的含量、肿瘤直径以及DNA模式对患者生存均具有预后价值。改进预测乳腺癌患者生存时间的方法可能对个体患者的治疗选择具有价值。
