人类乳腺癌中可溶性和核雌激素受体状态与预后的关系
Soluble and nuclear oestrogen receptor status in human breast cancer in relation to prognosis.
作者信息
Leake R E, Laing L, McArdle C, Smith D C
出版信息
Br J Cancer. 1981 Jan;43(1):67-71. doi: 10.1038/bjc.1981.9.
Abstract
The relationship between oestrogen receptor (RE) content of primary breast cancer and subsequent prognosis was examined with regard to nodal status. It was found that, within a particular nodal group, patients with tumours containing fully functional RE experienced a longer disease-free interval than those with RE- disease. An earlier observation that RE- primary disease gave rise to distant metastases as first site of recurrence more frequently than did RE+ disease, was not sustained. However, patients with RE+ primary disease had a much reduced chance of dying from cancer within a 3-year period.
摘要
研究了原发性乳腺癌雌激素受体（RE）含量与后续预后之间的关系，并考虑了淋巴结状态。结果发现，在特定的淋巴结组中，肿瘤含有完全功能性RE的患者比RE阴性疾病患者的无病间期更长。早期观察发现，RE阴性原发性疾病比RE阳性疾病更常以远处转移作为首次复发部位，但这一观察结果并未得到证实。然而，RE阳性原发性疾病患者在3年内死于癌症的几率大大降低。
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