母亲牙周炎与早产：系统评价与荟萃分析。

Maternal periodontitis and preterm birth: Systematic review and meta-analysis.

机构信息

Escuela de Medicina, Universidad Pedagógica y Tecnológica de Colombia, Tunja, Boyacá, Colombia.

Chair of Family Medicine, Miguel Hernandez University, San Juan de Alicante, Spain.

出版信息

Community Dent Oral Epidemiol. 2019 Jun;47(3):243-251. doi: 10.1111/cdoe.12450. Epub 2019 Feb 27.

DOI:10.1111/cdoe.12450

PMID:30812054

Abstract

AIM

To assess the association between periodontitis and preterm birth in women of childbearing age.

MATERIALS AND METHODS

This review included analytical case-control studies and prospective cohort studies evaluating the association between maternal periodontitis and preterm birth. Of the 3104 screened articles, 31 met the inclusion criteria for the review, and 20 met the quality criteria. The selected studies included a total of 10 215 women.

RESULTS

Twenty articles contributed to the meta-analysis; 16 used a case-control design, and 4 were prospective cohort studies. The study heterogeneity was low (Q = 24.2464; P = 0.1869; I = 21.63%). A positive association between maternal periodontitis and preterm birth was found in 60% of the studies. Under the random-effects model, meta-analysis gave an odds ratio (OR) of 2.01 (95% CI 1.71, 2.36), representing a significant positive association between the explanatory and outcome variables.

CONCLUSION

Pregnant mothers with periodontitis double the risk of preterm birth. There is a lack of international consensus for diagnosing maternal periodontitis.

摘要

目的

评估育龄妇女牙周炎与早产的关系。

材料与方法

本综述包括评估母体牙周炎与早产之间关系的分析性病例对照研究和前瞻性队列研究。在筛选出的 3104 篇文章中，有 31 篇符合综述纳入标准，有 20 篇符合质量标准。入选的研究共纳入了 10215 名女性。

结果

有 20 篇文章为荟萃分析提供了数据；其中 16 项采用病例对照设计，4 项为前瞻性队列研究。研究异质性较低（Q=24.2464；P=0.1869；I=21.63%）。有 60%的研究发现母体牙周炎与早产之间存在正相关。在随机效应模型下，荟萃分析得出比值比（OR）为 2.01（95%可信区间 1.71，2.36），表明解释变量与结果变量之间存在显著的正相关。