Facultad de Medicina y Psicología, Universidad Autónoma de Baja California, Calzada Universidad 14418, Parque Industrial Internacional, Tijuana 22300, Mexico.
Facultad de Ciencias Químicas e Ingeniería, Universidad Autónoma de Baja California, Calzada Universidad 14418, Parque Industrial Internacional, Tijuana 22300, Mexico.
Int J Environ Res Public Health. 2019 Feb 26;16(5):689. doi: 10.3390/ijerph16050689.
This study aims to determine the degree of acetylcholinesterase inhibition and neurological symptoms for each of the psychiatric disorders diagnosed in the farm workers of a rural population in the state of Baja California, Mexico. We conducted a cross-sectional study on 140 agricultural workers (exposed participants). The study was run using the Mini International Neuropsychiatric Interview Diagnostic Test (MINI), a pre-established questionnaire to diagnose the mental state of each agricultural worker. Analysis of enzymatic activity was carried out using the modified Ellman method. The results showed that, among agricultural workers with slightly inhibited enzymatic activity, 25% met the criteria for the diagnosis of major depression with suicidal attitudes, 23.9% with inhibited enzymatic activity showed generalized anxiety, 23.5% showed combined depression⁻anxiety, and 22% met the criteria for major depression and no psychiatric diagnosis disorder. These results suggest the need for the development of effective public-health strategies to inform farm workers about integrated pesticide management in order to prevent serious health complications.
本研究旨在确定墨西哥下加利福尼亚州农村地区农民中每种精神疾病的乙酰胆碱酯酶抑制程度和神经症状。我们对 140 名农业工人（暴露参与者）进行了横断面研究。该研究使用 Mini International Neuropsychiatric Interview Diagnostic Test（MINI）进行，这是一种预先确定的问卷，用于诊断每位农业工人的精神状态。酶活性分析采用改良的 Ellman 法进行。结果表明，在酶活性轻度抑制的农业工人中，25%符合有自杀倾向的重度抑郁症的诊断标准，23.9%的酶活性抑制者表现出广泛性焦虑，23.5%的人表现出抑郁-焦虑合并症，22%的人符合重度抑郁症和无精神疾病诊断障碍的标准。这些结果表明，需要制定有效的公共卫生策略，让农民了解综合农药管理，以防止严重的健康并发症。
