美国成年人代表性样本中农药暴露与睡眠健康之间的关联：来自 NHANES 2009-2014 的证据。
Association between pesticide exposure and sleep health among a representative sample of US adults: evidence from NHANES 2009-2014.
机构信息
Department of Nutritional Sciences, University of Michigan School of Public Health, Ann Arbor, MI, USA.
Department of Environmental Health Sciences, University of Michigan School of Public Health, Ann Arbor, MI, USA.
出版信息
BMC Public Health. 2021 Dec 1;21(1):2199. doi: 10.1186/s12889-021-12014-x.
BACKGROUND
Data suggest that pesticides interact with the melatonin receptor, which may influence sleep. However, the link between pesticides and sleep remains unexplored among the general adult population. This study evaluated unstratified and sex-stratified associations between urinary pesticide exposure (N = 4,478) and self-reported acute household pesticide exposure (N = 14,956), with sleep health outcomes within a nationally representative sample of US adults.
METHODS
Data from the National Health and Nutrition Examination Surveys (NHANES) 2009-2014 were combined for analysis of aim 1 and aim 2. Urinary pesticide metabolite concentrations served as biomarkers of pesticide exposure. Acute household pesticide exposure (if any chemical products were used in the home in the past seven days to control pests) was self-reported (yes/no). Insufficient sleep duration (< 7 h/night) and trouble sleeping (yes/no) were self-reported. Log-binomial regression models that accounted for complex survey weights and adjusted for confounders were used to compute prevalence ratios and 95% CI.
RESULTS
Log urinary 3-phenoxybenzoic acid (3-PBA) was related to a higher probability of insufficient sleep [1.09 (95% CI: 1.00, 1.20), p = 0.04] and trouble sleeping [1.14 (95% CI: 1.02, 1.27), p = 0.02] among males. Self-reported acute household pesticide exposure was associated with a higher probability of insufficient sleep duration [1.16 (95% CI: 1.02, 1.32), p = 0.03] and trouble sleeping [1.20 (95% CI: 1.01, 1.44), p = 0.04] in the unstratified sample. Sex-stratified findings showed that associations between acute household pesticide exposure and trouble sleeping only persisted among males [1.69 (95% CI: 1.27, 2.24), p < .001].
CONCLUSIONS
In summary, acute pesticide exposure may be detrimental to adult sleep health, particularly among US males.
背景
有数据表明，杀虫剂会与褪黑素受体相互作用，这可能会影响睡眠。然而，在普通成年人群中，杀虫剂与睡眠之间的联系仍未得到探索。本研究评估了未分层和按性别分层的尿中农药暴露（N=4478）与自我报告的家庭急性农药暴露（N=14956）与美国成年人全国代表性样本中睡眠健康结果之间的关系。
方法
对 2009-2014 年全国健康和营养检查调查（NHANES）的数据进行合并，以分析目的 1 和目的 2。尿中农药代谢物浓度用作农药暴露的生物标志物。家庭急性农药暴露（过去七天家中是否使用任何化学产品来控制害虫）是自我报告的（是/否）。睡眠不足（<7 小时/夜）和睡眠困难（是/否）是自我报告的。使用考虑到复杂调查权重并调整混杂因素的对数二项式回归模型来计算患病率比和 95%置信区间。
结果
尿中 3-苯氧基苯甲酸（3-PBA）的对数与男性睡眠不足的可能性增加相关[1.09（95%置信区间：1.00，1.20），p=0.04]和睡眠困难[1.14（95%置信区间：1.02，1.27），p=0.02]。自我报告的家庭急性农药暴露与睡眠不足的可能性增加相关[1.16（95%置信区间：1.02，1.32），p=0.03]和睡眠困难[1.20（95%置信区间：1.01，1.44），p=0.04]在未分层样本中。按性别分层的结果表明，家庭急性农药暴露与睡眠困难之间的关联仅在男性中持续存在[1.69（95%置信区间：1.27，2.24），p<0.001]。
结论
总之，急性农药暴露可能对美国成年人的睡眠健康有害，尤其是对美国男性。
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