Department of Biomedical Sciences for Health, University of the Study of Milan, 20133 Milan, Italy.
Int J Mol Sci. 2019 Feb 26;20(5):1019. doi: 10.3390/ijms20051019.
Neurotoxicity can be caused by numerous direct agents, of which toxic metals, organophosphorus pesticides, air pollution, radiation and electromagnetic fields, neurotoxins, chemotherapeutic and anesthetic drugs, and pathogens are the most important. Other indirect causes of neurotoxicity are cytokine and/or reactive oxygen species production and adoptive immunotherapy. The development of neurodegenerative diseases has been associated with neurotoxicity. Which arms are useful to prevent or eliminate neurotoxicity? The chelating agent calcium disodium ethylenediaminetetraacetic acid (EDTA)-previously used to treat cardiovascular diseases-is known to be useful for the treatment of neurodegenerative diseases. This review describes how EDTA functions as a therapeutic agent for these diseases. Some case studies are reported to confirm our findings.
神经毒性可由多种直接因素引起，其中有毒金属、有机磷农药、空气污染、辐射和电磁场、神经毒素、化疗和麻醉药物以及病原体最为重要。细胞因子和/或活性氧物质产生以及过继免疫疗法是神经毒性的其他间接原因。神经退行性疾病的发生与神经毒性有关。哪些方法有助于预防或消除神经毒性？先前用于治疗心血管疾病的络合剂钙二钠乙二胺四乙酸（EDTA）已知对治疗神经退行性疾病有效。本综述描述了 EDTA 如何作为这些疾病的治疗剂发挥作用。报告了一些病例研究以证实我们的发现。
