Rudenko T G, Dronov A F, Arutiunova V A, Vaisov A Sh
Antibiotiki. 1977 Mar;22(3):239-42.
The prolonged effect of a single application of a collagen-monomycin sponge was studied experimentally on albino rats on a model of a skin flat wound. The monomycin levels in the blood and tissues in the area of the sponge application for 14 days were determined by the biological method. The therapeutically effective concentration of monomycin, i.e. 3.8 gemma/ml was maintained in the general blood flow for 2 weeks. During this period the local antibiotic concentration was almost 5 times higher. The toxic effect of the collagen-monomycin complex was studied on rabbits and albino rats for 2 months with respect to the indices of the protein metabolism and the content of residual nitrogen and urea. The activity of cholinestrerase and the content of histamine in the blood were determined. No significant changes in the studied tests were observed during the period of the chronic experiment. The microstructure of the organs of the test animals did not differ from that of the intact animals. The collagen-monomycin complex had a prolonged antibacterial effect and was not toxic with respect to the the test animal.
在白化大鼠皮肤扁平伤口模型上，通过实验研究了单次应用胶原-放线菌素海绵的延长效果。采用生物学方法测定了在海绵应用部位的血液和组织中放线菌素水平，为期14天。放线菌素的治疗有效浓度，即3.8微克/毫升，在全身血流中维持了2周。在此期间，局部抗生素浓度几乎高出5倍。针对蛋白质代谢指标、残余氮和尿素含量，对兔和白化大鼠进行了2个月的研究，以考察胶原-放线菌素复合物的毒性作用。测定了血液中胆碱酯酶活性和组胺含量。在慢性实验期间，未观察到所研究指标的显著变化。实验动物器官的微观结构与完整动物的没有差异。胶原-放线菌素复合物具有延长的抗菌作用，对实验动物无毒。
