化疗治疗角膜巩膜黄色瘤：非手术治疗的空间
Corneoscleral xanthogranuloma treated with chemotherapy: The room for nonsurgical management.
作者信息
Mustafa Osama M, Daoud Yassine J
机构信息
Cornea, Cataract and Refractive Surgery Services, Division of Cornea, Wilmer Eye Institute, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.
College of Medicine, Alfaisal University, Riyadh, Saudi Arabia.
出版信息
Eur J Ophthalmol. 2020 Mar;30(2):NP23-NP26. doi: 10.1177/1120672119832187. Epub 2019 Feb 27.
PURPOSE
To describe a clinical case of corneoscleral xanthogranuloma, a rare manifestation of juvenile xanthogranuloma, and xanthoma disseminatum, which responded well to chemotherapy.
METHODS
Interventional case report and literature search.
RESULTS
A 9-year-old female patient with a disseminated disease showed complete regression of her corneoscleral xanthogranuloma with methotrexate and azathioprine therapy.
CONCLUSION
Since they are potentially blinding, corneoscleral xanthogranulomas are commonly surgically excised. While surgical resection has been widely advocated in the literature, immunosuppressive therapy alone may be a pertinent management line of corneoscleral xanthogranuloma, especially with systemic involvement.
目的
描述一例角膜巩膜黄色肉芽肿的临床病例，这是幼年性黄色肉芽肿的一种罕见表现，以及播散性黄瘤，该病例对化疗反应良好。
方法
介入性病例报告及文献检索。
结果
一名患有播散性疾病的9岁女性患者，其角膜巩膜黄色肉芽肿在接受甲氨蝶呤和硫唑嘌呤治疗后完全消退。
结论
由于角膜巩膜黄色肉芽肿可能导致失明，通常采用手术切除。虽然文献中广泛提倡手术切除，但单独的免疫抑制治疗可能是角膜巩膜黄色肉芽肿的一种合适治疗方法，尤其是在有全身受累的情况下。
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